Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
Acetaldehyde and retinaldehyde-metabolizing enzymes in colon and pancreatic cancers.
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DOI：
10.1007/978-3-319-09614-8_16
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发表时间：
2015
影响因子：
--
通讯作者：
Vasiliou, V.
中科院分区：
文献类型：
--
作者：
Singh, S.;Arcaroli, J.;Thompson, D. C.;Messersmith, W.;Vasiliou, V.
结直肠癌 (CRC) 和胰腺癌是癌症相关死亡的两个非常重要的因素。长期饮酒是这些癌症的重要危险因素。乙醇主要被乙醇脱氢酶氧化成乙醛，乙醛是一种能够通过与蛋白质和 DNA 形成加合物来引发肿瘤的物质。乙醛由 ALDH2、ALDH1B1 和 ALDH1A1 代谢为乙酸。视黄酸（RA）是细胞分化所必需的，并且已知可以阻止肿瘤的发展。 RA 由视黄醛通过视黄醛脱氢酶（特别是 ALDH1A1、ALDH1A2、ALDH1A3 和 ALDH8A1）合成。通过消除乙醛并产生 RA，ALDH 在癌症的发生和进展中发挥着至关重要的调节作用。 ALDH1催化活性已被用作识别和分离正常干细胞和癌症干细胞的生物标志物；它在肿瘤中的存在与结肠癌和胰腺癌的不良预后相关。总之，这些 ALDH 不仅是 CRC 和胰腺癌的生物标志物，而且在癌症的发生、进展和最终预后中发挥着重要的机制作用。
Colorectal (CRC) and pancreatic cancers are two very significant contributors to cancer-related deaths. Chronic alcohol consumption is an important risk factor for these cancers. Ethanol is oxidized primarily by alcohol dehydrogenases to acetaldehyde, an agent capable of initiating tumors by forming adducts with proteins and DNA. Acetaldehyde is metabolized by ALDH2, ALDH1B1 and ALDH1A1 to acetate. Retinoic acid (RA) is required for cellular differentiation and is known to arrest tumor development. RA is synthesized from retinaldehyde by the retinaldehyde dehydrogenases, specifically ALDH1A1, ALDH1A2, ALDH1A3 and ALDH8A1. By eliminating acetaldehyde and generating RA, ALDHs can play a crucial regulatory role in the initiation and progression of cancers. ALDH1 catalytic activity has been used as a biomarker to identify and isolate normal and cancer stem cells; its presence in a tumor is associated with poor prognosis in colon and pancreatic cancer. In summary, these ALDHs are not only biomarkers for CRC and pancreatic cancer but also play important mechanistic role in cancer initiation, progression and eventual prognosis.
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影响因子：
11.2
作者：
Charafe-Jauffret E;Ginestier C;Iovino F;Wicinski J;Cervera N;Finetti P;Hur MH;Diebel ME;Monville F;Dutcher J;Brown M;Viens P;Xerri L;Bertucci F;Stassi G;Dontu G;Birnbaum D;Wicha MS
通讯作者：
Wicha MS
影响因子：
2.6
作者：
Chen, Yi-Chyan;Peng, Giia-Sheun;Yin, Shih-Jiun
通讯作者：
Yin, Shih-Jiun
DOI：
10.1016/s0167-4838(02)00213-3
发表时间：
2002-04-01
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY
影响因子：
--
作者：
Gagnon, I;Duester, G;Bhat, PV
通讯作者：
Bhat, PV
DOI：
10.1073/pnas.0703478104
发表时间：
2007-06-12
影响因子：
11.1
作者：
Dalerba, Piero;Dylla, Scott J.;Clarke, Michael F.
通讯作者：
Clarke, Michael F.
影响因子：
3.7
作者：
Deng S;Yang X;Lassus H;Liang S;Kaur S;Ye Q;Li C;Wang LP;Roby KF;Orsulic S;Connolly DC;Zhang Y;Montone K;Bützow R;Coukos G;Zhang L
通讯作者：
Zhang L