Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education.
Neuroanatomical correlates of aging, cardiopulmonary fitness level, and education.
复制标题
DOI：
10.1111/j.1469-8986.2008.00676.x
复制
发表时间：
2008-09
期刊：
影响因子：
3.7
通讯作者：
Fabiani M
中科院分区：
文献类型：
--
作者：
Gordon BA;Rykhlevskaia EI;Brumback CR;Lee Y;Elavsky S;Konopack JF;McAuley E;Kramer AF;Colcombe S;Gratton G;Fabiani M
健身和教育可以防止衰老中的认知障碍。它们还可以抵消大脑中与年龄相关的结构变化。在这里，我们分析了脑脊液和灰色和白色物质的体积差异，沿着神经心理学数据，在不同年龄，健康和教育的成年人。认知表现与健康和教育相关。基于体素的形态测量用于结构磁共振图像的全脑分析。我们发现，在颞中叶、顶叶和额叶区域的灰色和白色物质中，存在与年龄相关的损失。与以前的研究一样，老年人的健康状况与同一区域保存的灰质有关。相比之下，高等教育预测保存白色物质在下额叶地区。这些数据表明，健身和教育都可以通过对大脑结构的单独影响来预测衰老中保留的认知功能。
Fitness and education may protect against cognitive impairments in aging. They may also counteract age-related structural changes within the brain. Here we analyzed volumetric differences in cerebrospinal fluid and gray and white matter, along with neuropsychological data, in adults differing in age, fitness, and education. Cognitive performance was correlated with fitness and education. Voxel-based morphometry was used for a whole-brain analysis of structural magnetic resonance images. We found age-related losses in gray and white matter in medial-temporal, parietal, and frontal areas. As in previous work, fitness within the old correlated with preserved gray matter in the same areas. In contrast, higher education predicted preserved white matter in inferior frontal areas. These data suggest that fitness and education may both be predictive of preserved cognitive function in aging through separable effects on brain structure.