DMT alters cortical travelling waves.
DMT alters cortical travelling waves.
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DOI：
10.7554/elife.59784
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发表时间：
2020-10-12
期刊：
影响因子：
7.7
通讯作者：
Carhart-Harris RL
中科院分区：
文献类型：
--
作者：
Alamia A;Timmermann C;Nutt DJ;VanRullen R;Carhart-Harris RL
迷幻药物是意识状态的有力调节器，因此是研究其神经生物学的有力工具。N，N，二甲基色胺(DMT)可以迅速诱导出一种以生动而精细的视觉意象为特征的极度沉浸式的意识状态。在这里，我们从一组接受DMT和(分别)安慰剂(生理盐水)的参与者中调查了DMT诱导的状态改变的电生理学相关性，同时指示他们闭上眼睛。与我们的假设一致，结果显示了与视觉刺激相似的皮质激活(即行波)的时空模式。此外，闭眼休息的典型自上而下的α频段节律明显减少，而自下而上的前向波显著增加。这些结果支持了最近的一个模型，该模型认为迷幻剂降低了“前科的精确权重”，从而改变了自上而下和自下而上传递信息的平衡。这些发现有力地证实了假说的本质，意味着发现了一个重要的机械论原理，支撑着迷幻诱导的状态改变。
Psychedelic drugs are potent modulators of conscious states and therefore powerful tools for investigating their neurobiology. N,N, Dimethyltryptamine (DMT) can rapidly induce an extremely immersive state of consciousness characterized by vivid and elaborate visual imagery. Here, we investigated the electrophysiological correlates of the DMT-induced altered state from a pool of participants receiving DMT and (separately) placebo (saline) while instructed to keep their eyes closed. Consistent with our hypotheses, results revealed a spatio-temporal pattern of cortical activation (i.e. travelling waves) similar to that elicited by visual stimulation. Moreover, the typical top-down alpha-band rhythms of closed-eyes rest were significantly decreased, while the bottom-up forward wave was significantly increased. These results support a recent model proposing that psychedelics reduce the ‘precision-weighting of priors’, thus altering the balance of top-down versus bottom-up information passing. The robust hypothesis-confirming nature of these findings imply the discovery of an important mechanistic principle underpinning psychedelic-induced altered states.