Effects of vitamin E and glutathione on glucose metabolism - Role of magnesium
Effects of vitamin E and glutathione on glucose metabolism - Role of magnesium
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DOI：
10.1161/01.hyp.34.4.1002
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发表时间：
1999-10-01
期刊：
影响因子：
8.3
通讯作者：
Paolisso, G
中科院分区：
文献类型：
--
作者：
Barbagallo, M;Dominguez, LJ;Paolisso, G
维生素E是一种抗氧化剂，已被证明可以改善胰岛素的作用。另一种天然抗氧化剂--谷氨酰胺也可能在血压和葡萄糖稳态中起重要作用，这与自由基在原发性高血压和糖尿病中的作用一致。我们的小组最近提出，还原型谷胱甘肽对葡萄糖代谢的影响可能是介导的，至少部分是通过细胞内镁水平（Mg-[i]）。最近的证据表明，维生素E提高谷胱甘肽水平，并可能在镁缺乏引起的心脏病变中发挥保护作用。为了直接研究维生素E补充对高血压患者胰岛素敏感性的影响，以及对还原型（GSH）和氧化型（GSSG）谷胱甘肽循环水平和Mg-[i]的影响，我们进行了一项为期4周的双盲研究，维生素E给药的随机研究在24例高血压患者中比较了600 mg/d与安慰剂的治疗效果，并在干预前后通过正葡萄糖钳夹法测量了全身葡萄糖处置（WBGD）、GSH/GSSG比值和Mg-[i]。分析两组患者WBGD、GSH/GSSG、Mg-[i]之间的关系。高血压受试者;，维生素E的施用显著增加了WBGD（25.56+/-0.61至31.75+/-0.53 μ mol/kg每分钟的去脂质量; P
Vitamin E is an antioxidant that has been demonstrated to improve insulin action. Glutathione, another natural antioxidant, may also be important in blood pressure and glucose homeostasis, consistent with the involvement of free radicals in both essential hypertension and diabetes mellitus. Our group has recently suggested that the effects of reduced glutathione on glucose metabolism may be mediated, at least in part, by intracellular magnesium levels (Mg-[i]). Recent evidence suggests that vitamin E enhances glutathione levels and may play a protective role in magnesium deficiency-induced cardiac lesions. To directly investigate the effects of vitamin E supplementation on insulin sensitivity in hypertension, in relation to the effects on circulating levels of reduced (GSH) and oxidized (GSSG) glutathione and on Mg-[i], we performed a 4-week, double-blind, randomized study of vitamin E administration (600 mg/d) versus placebo in 24 hypertensive patients and measured whole-body glucose disposal (WBGD) by euglycemic glucose clamp, GSH/GSSG ratios, and Mg-[i] before and after intervention. Thr relationships among WBGD, GSH/GSSG, and Mg-[i] in both groups were evaluated. In hypertensive subjects;, vitamin E administration significantly increased WBGD (25.56+/-0.61 to 31.75+/-0.53 mu mol/kg of fat-free mass per minute; P