Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?
Intrinsically disordered proteins and membranes: a marriage of convenience for cell signalling?
复制标题
DOI：
10.1042/bst20200467
复制
发表时间：
2020-12-18
影响因子：
3.9
通讯作者：
Mott HR
中科院分区：
文献类型：
--
作者：
Cornish J;Chamberlain SG;Owen D;Mott HR
几十年来，结构-功能范式一直指导着对参与细胞信号传递的分子的研究。然而，当考虑到信号传递过程中蛋白质和膜之间的合作时，这种范式的外围开始解体。与折叠结构域相比，内在无序区域在结合的混杂性、对特定环境的敏感性以及通过翻译后修饰进行调控方面具有明显的优势。低的序列复杂性和对带电残基的偏爱也有利于发生在脂质双层表面的多价静电相互作用。这篇综述着眼于蛋白质紊乱和膜之间成功联姻的原则，以及这种伙伴关系在修改和调节细胞过程中的信号传递方面的作用。小GTP酶的高变区(HVR)被强调为一个研究得很好的例子，表明一个短的内在无序区域在信号通路的微调中可以发挥微妙的作用。
The structure-function paradigm has guided investigations into the molecules involved in cellular signalling for decades. The peripheries of this paradigm, however, start to unravel when considering the co-operation between proteins and the membrane in signalling processes. Intrinsically disordered regions hold distinct advantages over folded domains in terms of their binding promiscuity, sensitivity to their particular environment and their ease of modulation through post-translational modifications. Low sequence complexity and bias towards charged residues are also favourable for the multivalent electrostatic interactions that occur at the surfaces of lipid bilayers. This review looks at the principles behind the successful marriage between protein disorder and membranes in addition to the role of this partnership in modifying and regulating signalling in cellular processes. The HVR (hypervariable region) of small GTPases is highlighted as a well-studied example of the nuanced role a short intrinsically disordered region can play in the fine-tuning of signalling pathways.
影响因子：
3.7
作者：
Yan X;Walkiewicz M;Carlson J;Leiphon L;Grove B
通讯作者：
Grove B