Role of microglia in neuronal degeneration and regeneration
Role of microglia in neuronal degeneration and regeneration
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DOI：
10.1007/s00281-009-0180-5
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发表时间：
2009-09
影响因子：
9
通讯作者：
L. Walter;H. Neumann
中科院分区：
文献类型：
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作者：
L. Walter;H. Neumann
小胶质细胞是中枢神经系统 (CNS) 的常驻巨噬细胞群，在正常和病理情况下都会主动扫描组织。它们产生的参与可能具有神经保护作用或神经毒性，从而导致疾病进展的改善或加剧。在这篇综述中，我们重点关注参与小胶质细胞反应的分子信号分子，并讨论了证明小胶质细胞在中枢神经系统疾病动物模型中的多种作用的观察结果。
Microglial cells, the resident macrophage population of the central nervous system (CNS), actively scan tissue under both normal and pathologic contexts. Their resulting engagement can become either neuroprotective or neurotoxic, leading to amelioration or aggravation of disease progression. In this review, we focus on the molecular signaling molecules involved in microglial responses and discuss observations demonstrating the diverse effects of microglia in animal models of CNS diseases.