A comparison of blood-brain barrier disruption by intracarotid iohexol and iodixanol in the rabbit.
A comparison of blood-brain barrier disruption by intracarotid iohexol and iodixanol in the rabbit.
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颈动脉内碘海醇和碘克沙醇对家兔血脑屏障破坏的比较。
DOI：
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
Michael R. Sage
中科院分区：
文献类型：
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作者：
John Wilcox;Alan J. Wilson;C. Evill;Michael R. Sage
使用兔模型来比较颈动脉内注射两种新型造影剂（非离子单体碘海醇和非离子二聚体碘克沙醇）对血脑屏障的影响。据推测，与相对较高渗透压的碘海醇（300 mgl/ml 时为 690 mOsm/kg）相比，低渗透压碘克沙醇（300 mgl/ml 时为 272 mOsm/kg）对血脑屏障的破坏较小。通过观察伊文思蓝染料的皮质染色程度来定性评估血脑屏障破坏的程度，并通过计算注射半球和未注射半球之间 99mTc-pertechnetate 摄取的差异来定量评估。结果统计分析表明，碘克沙醇和碘海醇对血脑屏障破坏的影响均显着大于等渗盐水（0.005 大于 p 大于 0.001），但在伊文思蓝染色（p 大于 0.05）或高锝酸盐摄取（p 小于 0.75）方面，碘克沙醇的效果与碘海醇没有显着差异。 .90)。因此，在实验性颈动脉血管造影后，低渗透压碘克沙醇在破坏血脑屏障方面比碘海醇没有显着优势。
A rabbit model was used to compare the effect on the blood-brain barrier of the intracarotid injection of two new contrast media: iohexol, a nonionic monomer, and iodixanol, a nonionic dimer. It was hypothesized that the low osmolality of iodixanol (272 mOsm/kg at 300 mgl/ml) would cause less disruption of the blood-brain barrier than the relatively higher osmolality of iohexol (690 mOsm/kg at 300 mgl/ml). The degree of blood-brain barrier disruption was assessed qualitatively, by observing the degree of cortical staining with Evans' Blue dye, and quantitatively, by calculating the difference in uptake of 99mTc-pertechnetate between injected and noninjected hemispheres. Statistical analysis of the results showed that both iodixanol and iohexol had a significantly greater effect on blood-brain barrier disruption than did isotonic saline (0.005 greater than p greater than .001), but that the effect of iodixanol was not significantly different from that of iohexol with respect to either Evans' Blue staining (p greater than .05) or pertechnetate uptake (.75 less than p less than .90). Thus, the low-osmolality iodixanol has no significant advantage over iohexol in terms of blood-brain barrier disruption after experimental carotid angiography.