Does EEG (visual and quantitative) reflect mental impairment in subcortical vascular dementia?
Does EEG (visual and quantitative) reflect mental impairment in subcortical vascular dementia?
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DOI：
10.1016/j.jns.2007.01.046
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发表时间：
2007-06-15
影响因子：
4.4
通讯作者：
Kowalski, J.
中科院分区：
文献类型：
--
作者：
Gawel, M.;Zalewska, E.;Kowalski, J.
这项研究的目的是确定视觉和定量脑电(QEEG)参数的结果是否与皮质下血管性痴呆(SVD)的智力损害有关，SVD是老年人认知障碍的最常见原因之一。在SVD中，就像在阿尔茨海默病中一样，胆碱能传递也存在障碍。突触电位改变所表现的胆碱能缺陷反映在脑电信号中。材料：31例可能的SVD患者(根据NINCDS-Airen和T.Erkinjty‘s标准)，平均年龄72.3岁(男性-43%，女性-57%)和14名健康对照组，平均年龄72.3岁(男性-57%，女性-43%)。根据简易智力量表检查(MMSE)，将SVD组分为轻度痴呆和中度痴呆两个亚组，用Medelec和NeuroScan 4.2系统记录脑电。视觉脑电结果根据慢波存在的病理改变的八度分级进行分类。然后制作QEEG。计算α/慢波功率比、平均波频。结果：轻度和中度痴呆SVD亚组QEEG差异有统计学意义(P<；0.05)，而视觉EEG差异无统计学意义。定量脑电参数如α/慢波比值或平均波频与精神障碍显著相关(p<；0.001)，而视觉分析脑电异常程度与简易精神状态检查结果无显著相关性。结论：只有定量脑电与精神障碍相关。视觉脑电技术作为一种不太精确的工具，不能反映胆碱能缺陷所致的SVD的智力损害。(C)2007 Elsevier B.V.保留所有权利。
The aim of this study was to determine if the results of visual and quantitative EEG (QEEG) parameters reveal a correlation with mental impairment in subcortical vascular dementia (SVD), one of the most frequent causes of cognitive impairment in the elderly. In SVD, like in Alzheimer's disease disturbances were found in cholinergic transmission. The cholinergic deficit as manifested in changes of synaptic potentials is reflected in EEG signals.Material: 31 patients with probable SVD (according to NINCDS-AIREN and T. Erkinjuntii's criteria) and mean age 72.3 yrs;(M-43%, F-57%) and 14 healthy control subjects with mean age of 72.3 yrs (M-57%, F-43%). According to the Mini Mental Scale Examination (MMSE) the SVD group was divided into two subgroups with mild and moderate dementia, their EEGs being recorded with a Medelec and Neuroscan 4.2 system. Visual EEG findings were classified with the use of eight-degree scale of pathological changes by the presence of slow waves. Then QEEGs were made. The following parameters were calculated: alpha/slow wave power ratios, the mean wave frequency in all and in some selected derivations.Results: A significant difference was found between QEEGs in SVD subgroups with mild and moderate dementia (p < 0.05), but there was no significant difference between visual EEGs. A significant correlation between QEEG parameters such as alpha/slow wave ratio or mean wave frequency and mental impairment (according to MMSE results) was found (p < 0.001), but there was no significant correlation between degree of EEG abnormalities in visual analysis and MMSE results.Conclusion: Only QEEGs are correlated with mental impairment in SVD. Visual EEG technique as a less precise tool does not reflect the mental impairment in SVD due to cholinergic deficit. (c) 2007 Elsevier B.V. All rights reserved.