Testosterone Insufficiency in Human Immunodeficiency Virus-Infected Women: A Cross-Sectional Study
Testosterone Insufficiency in Human Immunodeficiency Virus-Infected Women: A Cross-Sectional Study
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DOI：
10.1016/j.esxm.2018.10.002
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发表时间：
2019-03-01
期刊：
影响因子：
2.6
通讯作者：
Nievaard-Boon, Marian A. F.
中科院分区：
文献类型：
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作者：
Laan, Ellen T. M.;Prins, Jan M.;Nievaard-Boon, Marian A. F.
导语：HIV感染已成为一种慢性病，优化健康状态是HIV感染者护理的重要目标。睾酮功能不全（TI）可损害健康状况，但对hiv感染妇女中睾酮功能不全的患病率及其可能的相关因素知之甚少。目的：调查门诊HIV感染妇女TI患病率，探讨TI与性功能、疲劳、健康状况、抑郁的关系。方法：在荷兰阿姆斯特丹大学医学中心HIV门诊就诊的56名年龄为bb0 = 18岁的HIV感染妇女。他们抽取血样进行内分泌测试，并填写6份有效问卷，测量性功能、疲劳、健康状况和抑郁程度。主要结果测量：评估TI、女性性功能指数、女性性困扰量表（修订版）、多维疲劳量表、医学结果研究简表36项健康调查和贝克抑郁量表。结果：TI患病率较高，为37%。血浆病毒载量和CD4细胞计数在有或没有TI的妇女之间没有差异。临床疲劳、身体疲劳和认知功能受损在TI患者中更为普遍。患有TI的女性也倾向于报告性欲下降、身体活动减少、精神疲劳增加、身体功能下降、健康困扰增加和临床抑郁。结论：我们建议在所有有典型TI症状的hiv阳性妇女中，测量睾酮，并且在患有TI的妇女中，睾酮替代可作为一种治疗选择。然而，考虑到在没有TI的hiv阳性妇女中投诉也很普遍，对这些投诉的妇女的方法应该包括性和心理评估。版权所有，作者2018年由爱思唯尔公司代表国际性医学学会出版。这是一篇基于CC BY-NC-ND许可（http://creativecommons.org/licenses/by-nc-nd/4.0/）的开放获取文章。
Introduction: Now that HIV infection has become a chronic disease, optimizing health status is an important goal of care for HIV-infected patients. Testosterone insufficiency (TI) can compromise health status, but little is known about the prevalence of TI and possible related factors in HIV-infected women.Aim: To investigate the prevalence of TI among HIV-infected women attending our HIV outpatient clinic, and to study the relationship between TI and sexual function, fatigue, health status, and depression.Methods: 56 HIV-infected women aged >= 18 years who attended the HIV outpatient clinic of the Amsterdam University Medical Center, The Netherlands, were included. Blood samples were taken for endocrinologic testing and patients filled out 6 validated questionnaires measuring sexual function, fatigue, health, and depression.Main Outcome Measure: TI, the Female Sexual Function Index, the Female Sexual Distress Scale-Revised, the Multidimensional Fatigue Inventory, the Medical Outcomes Studies Short Form 36-item health survey, and the Beck Depression Inventory were assessed.Results: A relatively high prevalence of TI, 37%, was found. Plasma viral load and CD4 cell count did not differ between women with or without TI. Clinical fatigue, physical fatigue, and impaired cognitive function were significantly more prevalent in women with TI. Women with TI also tended to report decreased sexual desire, reduced physical activity, increased mental fatigue, reduced physical function, increased health distress, and clinical depression.Conclusion: We recommend that in all HIV-positive women with complaints typical for TI, testosterone is measured, and that in women with TI, testosterone replacement be considered as a treatment option. However, given that complaints are also prevalent in HIV-positive women without TI, the approach to women with these complaints should include sexual and psychological evaluation. Copyright (C) 2018, The Authors. Published by Elsevier Inc. on behalf of the International Society for Sexual Medicine. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).