Effects of concentration and duration of toluene exposure on Sidman avoidance in rats.
Effects of concentration and duration of toluene exposure on Sidman avoidance in rats.
复制标题
甲苯暴露浓度和持续时间对大鼠西德曼回避的影响。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
H. Aikawa
中科院分区：
文献类型：
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作者：
S. Shigeta;T. Misawa;H. Aikawa
15只已建立Sidman回避反应的大鼠，首先暴露在空气中4小时，然后随机暴露于350、750或1500 ppm的甲苯蒸气中1、2或4小时，然后在终止甲苯暴露后80分钟观察对杠杆挤压行为的影响。试验清楚地揭示了浓度、暴露时间和试验时间对甲苯杠杆挤压的影响。利用本实验所采用的技术，可以根据甲苯浓度确定最小有效暴露条件，暴露时间为1500ppm，暴露时间为2小时。这些发现表明，这项技术在评估甲苯的行为毒性方面是有用的。
Fifteen rats in which responding under the Sidman avoidance schedule had been established were first exposed to air for 4 hr, then randomly to 350, 750 or 1,500 ppm of toluene vapor for 1, 2 or 4 hr, following which the effects on lever pressing behavior were investigated for 80 min after the termination of toluene exposure. The effect of concentration, exposure duration and test period on lever pressing of toluene was revealed clearly in the test. Using the technique adopted in this experiment, one could be determining the minimal effective exposure condition in terms of toluene concentration and exposure duration is 1,500 ppm for 2 hr. These findings suggest the usefulness of this technique in assessing the behavioral toxicity of toluene.