ASSOCIATION OF PRIMARY SCLEROSING CHOLANGITIS WITH HLA-B8
ASSOCIATION OF PRIMARY SCLEROSING CHOLANGITIS WITH HLA-B8
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DOI：
10.1136/gut.24.1.38
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发表时间：
1983-01-01
期刊：
影响因子：
24.5
通讯作者：
SHERLOCK, S
中科院分区：
文献类型：
--
作者：
CHAPMAN, RW;VARGHESE, Z;SHERLOCK, S
研究人员对 25 名原发性硬化性胆管炎患者的 HLA 抗原频率进行了研究，并与 561 名肾脏捐献者组成的对照组进行了比较。十四名患者还患有溃疡性结肠炎。与对照组 (25%) 相比，原发性硬化性胆管炎患者的 HLA-B8 频率 (60%) 显着增加 (P < 0.001)。在 8 名溃疡性结肠炎患者中发现了 HLA-B8。与对照组（30%）相比，HLA-B12 频率显着降低（8%）（P < 0.02）。肝脏组织学检查显示，66% 的 HLA-B8 阳性患者和 50% 的 HLA-B8 阴性患者出现片状坏死。原发性硬化性胆管炎组中经常发现低滴度的血清自身抗体，但与 HLA-B8 的存在不对应。 IgM 和 IgG 血清浓度升高与 HLA-B8 无关。在原发性硬化性胆管炎患者中，存在与主要组织相容性复合物的B位点密切相关的疾病易感基因，该基因可能被溃疡性结肠炎等其他因素所改变。患有溃疡性结肠炎和 HLA-B8 的患者可能特别容易患上原发性硬化性胆管炎。
The frequency of HLA antigens was studied in 25 patients with primary sclerosing cholangitis and compared with a control group of 561 kidney donors. Fourteen patients also had ulcerative colitis. A significant increase in the frequency of HLA-B8 (60%) was found in the primary sclerosing cholangitis patients compared with controls (25%) (P < 0.001). HLA-B8 was found in 8 patients with ulcerative colitis. The frequency of HLA-B12 was significantly decreased (8%) compared with controls (30%) (P < 0.02). Piecemeal necrosis was observed on liver histology in 66% of HLA-B8 positive and 50% of HLA-B8 negative patients. Low titers of serum autoantibodies were frequently found in the primary sclerosing cholangitis group, but did not correspond to the presence of HLA-B8. Raised serum concentrations of IgM and IgG were not related to HLA-B8. In patients with primary sclerosing cholangitis there exists a disease susceptibility gene closely associated with the B locus of the major histocompatibility complex which may be modified by other factors such as ulcerative colitis. Patients with ulcerative colitis and HLA-B8 may be particularly liable to develop primary sclerosing cholangitis.