Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage
Massage Therapy Attenuates Inflammatory Signaling After Exercise-Induced Muscle Damage
复制标题
DOI：
10.1126/scitranslmed.3002882
复制
发表时间：
2012-02-01
影响因子：
17.1
通讯作者：
Tarnopolsky, Mark A.
中科院分区：
文献类型：
--
作者：
Crane, Justin D.;Ogborn, Daniel I.;Tarnopolsky, Mark A.
按摩疗法通常用于骨骼肌的物理康复期间，以减轻疼痛并促进损伤的恢复。虽然有证据表明按摩可以缓解受伤肌肉的疼痛，但按摩如何影响细胞功能仍不清楚。为了评估按摩的效果，我们对11名运动性肌肉损伤的年轻男性参与者的股四头肌进行按摩治疗或不进行治疗。在基线、按摩治疗10分钟后立即和恢复2.5小时后，从股四头肌（股外侧肌）采集肌肉活检。我们发现，按摩激活了机械传导信号通路粘着斑激酶（FAK）和细胞外信号调节激酶1/2（ERK 1/2），增强了线粒体生物合成信号传导[核过氧化物酶体增殖物激活受体γ辅激活因子1 α（PGC-1 α）]，并减轻了由运动诱导的肌肉创伤引起的核因子κ B（NF kappa B）（p65）核积聚的增加。此外，尽管对肌肉代谢物（糖原，乳酸盐）没有影响，但按摩减弱了炎症细胞因子肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）的产生，并减少了热休克蛋白27（HSP 27）磷酸化，从而减轻了肌纤维损伤引起的细胞应激。总而言之，当对通过运动急性损伤的骨骼肌进行按摩治疗时，按摩疗法似乎通过减少炎症和促进线粒体生物合成而具有临床益处。
Massage therapy is commonly used during physical rehabilitation of skeletal muscle to ameliorate pain and promote recovery from injury. Although there is evidence that massage may relieve pain in injured muscle, how massage affects cellular function remains unknown. To assess the effects of massage, we administered either massage therapy or no treatment to separate quadriceps of 11 young male participants after exercise-induced muscle damage. Muscle biopsies were acquired from the quadriceps (vastus lateralis) at baseline, immediately after 10 min of massage treatment, and after a 2.5-hour period of recovery. We found that massage activated the mechanotransduction signaling pathways focal adhesion kinase (FAK) and extracellular signal-regulated kinase 1/2 (ERK1/2), potentiated mitochondrial biogenesis signaling [nuclear peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha)], and mitigated the rise in nuclear factor kappa B (NF kappa B) (p65) nuclear accumulation caused by exercise-induced muscle trauma. Moreover, despite having no effect on muscle metabolites (glycogen, lactate), massage attenuated the production of the inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) and reduced heat shock protein 27 (HSP27) phosphorylation, thereby mitigating cellular stress resulting from myofiber injury. In summary, when administered to skeletal muscle that has been acutely damaged through exercise, massage therapy appears to be clinically beneficial by reducing inflammation and promoting mitochondrial biogenesis.