Central epinergic inhibition of corticosterone release in rat.
Central epinergic inhibition of corticosterone release in rat.
复制标题
大鼠皮质酮释放的中枢表能抑制。
DOI：
10.1016/0024-3205(81)90505-1
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发表时间：
1981
期刊：
影响因子：
6.1
通讯作者：
Carroll,BJ
中科院分区：
文献类型：
--
作者：
Roth,KA;Katz,RJ;Sibel,M;Mefford,IN;Barchas,JD;Carroll,BJ
将已知抑制苯乙醇胺-N-甲基转移酶（EC 2.1.1.28）（肾上腺素合成途径中的最终酶）的药物给予大鼠，并研究它们对垂体-肾上腺功能的影响。 2, 3-二氯-α-甲基苄胺 (DCMB) 可使基础大鼠和应激大鼠的血浆皮质酮水平出现剂量相关的增加。肾上腺素这种强直抑制作用的核心性质的证据是它在肾上腺脱髓大鼠中持续存在。 2-氯-3-三氟甲基-α-苄胺（CTFMB）给药可升高血浆皮质酮，并且这种作用与假手术大鼠和肾上腺去髓大鼠中下丘脑肾上腺素浓度的降低高度相关。这些发现支持强直性表能抑制垂体-肾上腺功能。
Drugs known to inhibit phenylethanolamine-N-methyltransferase (EC 2.1.1.28), the final enzyme in the epinephrine synthetic pathway were administered to rats and their effects on pituitary-arenal function studied. 2, 3-Dichloro-α-methylbenzylamine (DCMB) produced dose-related increases in plasma corticosterone in basal and stressed rats. Evidence for the central nature of this tonic inhibitory effect of epinephrine was its continued presence in adrenal demedullated rats. 2-chloro-3-trifluoromethyl-α-benzylamine (CTFMB) administration elevated plasma corticosterone and this effect was highly correlated to the decrease in hypothalamic epinephrine concentration in both sham operated and adrenal demedullated rats. These findings argue for tonic epinergic inhibition of pituitary-adrenal function.