Kohamaic acids A and B, novel cytotoxic sesterterpenic acids, from the marine sponge Ircinia sp.
Kohamaic acids A and B, novel cytotoxic sesterterpenic acids, from the marine sponge Ircinia sp.
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DOI：
10.1246/cl.2001.176
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发表时间：
2001-02-05
影响因子：
1.6
通讯作者：
Uemura, D
中科院分区：
文献类型：
--
作者：
Kokubo, S;Yogi, K;Uemura, D
从海绵Irciniasp.中分离得到两个新的二倍半萜酸类化合物，经光谱和化学分析确定了它们的绝对立体化学结构。它们在C15的构型与以前分离的二倍半萜不同。该结果表明存在（14 Z）-香叶基法呢基焦磷酸，其在自然界中尚不为人所知。
Two new sesterterpenic acids, which exhibited moderate cytotoxicity, were isolated from the marine sponge Ircinia sp. Their absolute stereochemistries were determined by spectroscopic and chemical analyses. Their configurations at C15 were different from those of previously isolated sesterterpenes. This result suggests the existence of a (14Z)-geranylfarnesyl pyrophosphate, which is yet unknown in nature.