Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy.
Discovery of immunogenic cell death-inducing ruthenium-based photosensitizers for anticancer photodynamic therapy.
复制标题
DOI：
10.1080/2162402x.2020.1863626
复制
发表时间：
2020-12-29
期刊：
影响因子：
7.2
通讯作者：
Gujar S
中科院分区：
文献类型：
--
作者：
Konda P;Lifshits LM;Roque JA 3rd;Cole HD;Cameron CG;McFarland SA;Gujar S
我们报告了一类新的钌（Ru）为基础的光敏剂，诱导黑色素瘤细胞与近红外光激活后，有效的细胞毒性。除了直接的细胞毒性作用之外，这种基于Ru的光动力疗法诱导黑素瘤细胞中的免疫原性细胞死亡，其可以在治疗上用于建立保护性抗肿瘤免疫。
We report a new class of ruthenium (Ru)-based photosensitizers that induce potent cytotoxicity in melanoma cells following activation with NIR light. In addition to the direct cytotoxic effect, this Ru-based photodynamic therapy induces immunogenic cell death in melanoma cells that can be therapeutically exploited to establish protective antitumor immunity.