CHRONIC DISEASE IN FORMER COLLEGE STUDENTS .11. EARLY PRECURSORS OF NONFATAL STROKE
CHRONIC DISEASE IN FORMER COLLEGE STUDENTS .11. EARLY PRECURSORS OF NONFATAL STROKE
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DOI：
10.1093/oxfordjournals.aje.a121351
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发表时间：
1971-01-01
影响因子：
5
通讯作者：
WING, AL
中科院分区：
文献类型：
--
作者：
PAFFENBARGER, RS;WING, AL
帕芬巴格河美国，Jr.（加利福尼亚州）国务院加州伯克利公共卫生部94704）和A. L.翼大学毕业生慢性病。十一.非致命性中风的早期前兆。Amer J Epidem 94：524-530，1971。在1916-1940年就读于哈佛大学的10327名男性中，有102人报告了医生诊断的中风，他们在1966年返回了一份可用的自我管理的邮件问卷。一个67%的回应是从一个单一的邮件和答案的可靠性和有效性被认为是普遍可以接受的。中风发生时受试者的平均年龄为54岁，而受访者的平均年龄范围从最早的五个大学班级的64岁到最近的五个班级的47岁。对这些前学生的大学医疗记录进行检查，发现年轻人有四个特点，容易增加晚年非致命性中风的发生率：血压水平较高，身高体重增加，身材矮小，吸烟。四个特征中任何一个的配对组合对卒中发生率有相加或更大的影响。同样，1966年这些学生的问卷调查结果显示，与非致命性卒中患病率增加相关的四个高危特征：高血压、冠心病、糖尿病和父母高血压史。高血压对非致命性中风的患病率影响最大，无论是单独还是与其他三个特征配对。通过问卷调查确定的前学生的高血压和父母的高血压史都是非致命性中风的更好预测因子，而不是大学中评估的高血压水平。
Paffenbarger, R. S., Jr. (Calif. State Dept. of Public Health, Berkeley, Calif. 94704) and A. L. Wing. Chronic disease in former college students. XI. Early precursors of nonfatal stroke.Amer J Epidem94: 524–530, 1971.—Doctor-diagnosed stroke was reported by 102 of 10, 327 men who had attended Harvard University, 1916–1940, and who had returned a usable, self-administered mail questionnaire in 1966. A 67% response was achieved from a single mailing and the reliability and validity of answers were found to be generally acceptable. The mean age of subjects was 54 years at time of stroke occurrence, while the mean age of respondents ranged from 64 for the five earliest college classes to 47 for the five most recent classes. Examination of university medical records of these former students revealed four characteristics in youth that predisposed to increased incidence of nonfatal stroke in later life: higher levels of blood pressure, increased weight for height, shorter body stature, and cigarette smoking. Paired combinations of any of the four characteristics had an additive or greater effect on stroke incidence. Similarly, questionnaire responses in 1966 from these former students revealed four high risk characteristics that associated with an increased prevalence of nonfatal stroke: high blood pressure, coronary heart disease, diabetes, and a history of parental hypertension. High blood pressure exerted the strongest influence on prevalence of nonfatal stroke, both singly and when paired with the three other characteristics. High blood pressure in the former students and a history of parental high blood pressure, both determined by questionnaire, were each better predictors of nonfatal stroke than higher levels of blood pressure assessed in college.