Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment
Diverse Metabolic Profiles of a Streptomyces Strain Isolated from a Hyper-arid Environment
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DOI：
10.1021/np200470u
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发表时间：
2011-09-01
影响因子：
5.1
通讯作者：
Jaspars, Marcel
中科院分区：
文献类型：
--
作者：
Rateb, Mostafa E.;Houssen, Wael E.;Jaspars, Marcel
从智利超干旱的阿塔卡马沙漠土壤中分离出的链霉菌C34菌株的代谢特征取决于其生长所用的培养基。使用一系列培养基对该菌株应用OSMAC方法，导致从罕见的22元大环内酯聚酮化合物中分离和鉴定出三种新化合物，命名为chaxalactins A-C（1-3）。此外，还检测到已知化合物去铁胺E（4）、潮霉素A（5）和5“-二氢潮霉素A（6）。分离的化合物通过NMR光谱和精确的质谱分析进行表征。化合物1-3对革兰氏阳性菌有较强的抗菌活性，但对革兰氏阴性菌的抗菌活性较弱。
The metabolic profile of Streptomyces sp. strain C34, isolated from the Chilean hyper-arid Atacama Desert soil, is dependent on the culture media used for its growth. The application of an OSMAC approach on this strain using a range of cultivation media resulted in the isolation and identification of three new compounds from the rare class of 22-membered macrolactone polyketides, named chaxalactins A-C (1-3). In addition, the known compounds deferroxamine E (4), hygromycin A (5), and 5 ''-dihydro-hygromycin A (6) were detected. The isolated compounds were characterized by NMR spectroscopy and accurate mass spectrometric analysis. Compounds 1-3 displayed strong activity against Gram-positive but weak activity Gram-negative strains tested.