High prevalence of end-stage renal disease of unknown origin in Aguascalientes Mexico: role of the registry of chronic kidney disease and renal biopsy in its approach and future directions.
High prevalence of end-stage renal disease of unknown origin in Aguascalientes Mexico: role of the registry of chronic kidney disease and renal biopsy in its approach and future directions.
复制标题
DOI：
10.1093/ckj/sfaa229
复制
发表时间：
2021-04
影响因子：
4.6
通讯作者：
Arreola Guerra JM
中科院分区：
文献类型：
--
作者：
Gutierrez-Peña M;Zuñiga-Macias L;Marin-Garcia R;Ovalle-Robles I;García-Díaz AL;Macías-Guzmán MJ;Delgado-Bentites A;Macías-Diaz DM;Prado-Aguilar CA;Vega de la Rosa A;Delgadillo-Castañeda R;Chew-Won A;Reyes-Acevedo R;Reyes-Campos DM;Martínez-Guevara MA;Mendoza-Enciso EA;Nava-Becerra B;Piza-Jiménez MA;Arreola Guerra JM
慢性肾脏病（CKD）是对公共卫生系统影响最大的疾病之一。在过去的几十年里，慢性肾病在墨西哥的相关性有所增加，随之而来的是肾脏疾病治疗的巨大费用。墨西哥没有可靠的 CKD 统计数据。 2018 年 6 月，阿瓜斯卡连特斯州政府呼吁所有医疗机构建立已治疗终末期肾病 (ESRD) 的国家登记处。在同一系统中，肾活检结果登记处包括自 2012 年以来在阿瓜斯卡连特斯州获得的所有天然肾活检样本。我们在此描述了阿瓜斯卡连特斯州 CKD 和肾活检登记处包含的患者的患病率、发病率和特征。截至 2020 年 4 月，该州已记录了 2827 名接受肾脏替代治疗 (RRT) 的患者、1877 名接受透析的患者以及 950 名接受移植的患者。透析患者的患病率为每百万人口 1326 人 (p.m.p.)，如果包括移植个体，则为 1997 年 p.m.p.。 2019 年接受治疗的 ESRD 发病率为 336 p.m.p. (n = 474) 的个体平均年龄为 45.6 岁（标准差 ±18），且男性比例较高 (61%)。开始 RRT 的年龄呈双峰分布。第一个也是最显着的峰值出现在 20 岁至 40 岁之间，通常是不明原因 CKD 的结果 (73%)。第二个高峰是50岁至70岁之间，CKD通常是糖尿病和全身性动脉高血压的结果（59.6%）。自 2012 年 1 月以来，已记录了 423 例活检。患者年龄在 20 至 30 岁之间 (n = 112)，最常见的诊断是局灶节段性肾小球硬化症 (FSGS) (54%)。阿瓜斯卡连特斯州接受治疗的 ESRD 患病率很高。该病多见于20岁至40岁的年轻人，男性明显多见。在这个年龄组中，主要的临床诊断是不明原因的CKD，最常见的活检诊断是FSGS。
Chronic kidney disease (CKD) is one of the pathologies with the greatest impact on the public health system. Over the last few decades, the relevance of CKD in Mexico has increased, with associated overwhelming costs for care of renal disease. There are no reliable CKD statistics in Mexico. In June 2018, the government of Aguascalientes called on all Health Institutions to create a state registry of treated end-stage renal disease (ESRD). In the same system, a renal biopsy result registry included all the native kidney biopsies obtained in the state of Aguascalientes since 2012. We herein describe the prevalence, incidence and characteristics of the patients included in the CKD and renal biopsy registry in the state of Aguascalientes. As of April 2020, the state has documented 2827 patients on renal replacement therapy (RRT), 1877 on dialysis and 950 that have been transplanted. The prevalence of patients on dialysis is 1326 per million population (p.m.p.), and if transplanted individuals are included, it is 1997 p.m.p. The incidence of treated ESRD in 2019 was 336 p.m.p. (n = 474) in individuals with an average age of 45.6 years (standard deviation ±18), and in a higher proportion of men (61%). There is a bimodal distribution of the age at which RRT was initiated. The first and the most significant peaks are between the ages of 20 and 40 years and are usually the result of CKD of unknown cause (73%). The second peak is between 50 and 70 years of age, and CKD is usually the result of diabetes mellitus and systemic arterial hypertension (59.6%). Since January 2012, 423 biopsies have been recorded. The patient’s ages were between 20 and 30 years (n = 112), and the most frequent diagnosis was focal segmental glomerulosclerosis (FSGS) (54%). The prevalence of treated ESRD in the state of Aguascalientes is high. The disease mostly afflicts young people between 20 and 40 years of age, and there is a clear male predominance. In this age group, the main clinical diagnosis is CKD of unknown origin, and the most frequent biopsy diagnosis was FSGS.
登录
查看更多内容
影响因子：
2.3
作者：
Weaver VM;Fadrowski JJ;Jaar BG
通讯作者：
Jaar BG
影响因子：
19.6
作者：
Fischer, Rebecca S. B.;Vangala, Chandan;Murray, Kristy O.
通讯作者：
Murray, Kristy O.
影响因子：
--
作者：
Alhusaini AM;Faddah LM;El Orabi NF;Hasan IH
通讯作者：
Hasan IH
影响因子：
4.6
作者：
Song C;Fu B;Zhang J;Zhao J;Yuan M;Peng W;Zhang Y;Wu H
通讯作者：
Wu H
影响因子：
13.2
作者：
Wijkstrom, Julia;Gonzalez-Quiroz, Marvin;Wernerson, Annika
通讯作者：
Wernerson, Annika