HLA susceptibility genes in rheumatoid factor positive juvenile rheumatoid arthritis.
HLA susceptibility genes in rheumatoid factor positive juvenile rheumatoid arthritis.
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发表时间：
1990-11
影响因子：
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通讯作者：
R. Vehe;A. Begovich;B. Nepom
中科院分区：
文献类型：
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作者：
R. Vehe;A. Begovich;B. Nepom
类风湿因子阳性（血清反应阳性）幼年类风湿关节炎（JRA）是一种相对罕见但严重的 JRA 形式，其临床特征与典型的成人发病类风湿关节炎相同。对这些患者的免疫遗传学分析支持了这样的观点，即这可能代表了相同疾病过程的儿童期发病。在本报告中，我们回顾了该疾病的临床特征以及之前的 HLA 研究。我们报告了一小部分患者的完整的基于 DNA 的 HLA 分型，并讨论了结果的机制意义。
Rheumatoid factor positive (seropositive) juvenile rheumatoid arthritis (JRA) is a relatively uncommon but severe form of JRA which shares clinical features with classical adult onset rheumatoid arthritis. Immunogenetic analysis of these patients supports the concept that this likely represents childhood onset of the same disease process. In this report, we review the clinical features as well as previous HLA studies of this disease. We report complete DNA based HLA typing of a small group of these patients, and discuss mechanistic implications of the results.