Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid subunits.
Stictamides A-C, MMP12 inhibitors containing 4-amino-3-hydroxy-5-phenylpentanoic acid subunits.
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DOI：
10.1021/jo200241h
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发表时间：
2011-05-20
影响因子：
3.6
通讯作者：
Williams, Philip G.
中科院分区：
文献类型：
--
作者：
Liang, Zhibin;Sorribas, Analia;Sulzmaier, Florian J.;Jimenez, Jorge I.;Wang, Xin;Sauvage, Thomas;Yoshida, Wesley Y.;Wang, Guangyi;Ramos, Joe W.;Williams, Philip G.
An extensive study of the secondary metabolites produced by a new Sticta sp. of lichen has led to the isolation of three new compounds containing the 4-amino-3-hydroxy-5-phenylpentanoic acid residue (Ahppa). The structures of stictamides A-C (1–3) were assigned by 2D NMR spectroscopic and chemical methods. Due to extensive epimerization of the Ahppa residue observed after acid hydrolysis, the configuration of this unit was deduced through conversion of 1 to an appropriate derivative and application of our recently developed statine NMR database. Evaluation of stictamide A against a panel of disease-relevant proteases showed it inhibited MMP12 at 2.3 µM and significantly reduced invasion in the human glioma cell line U87MG. Docking studies suggest stictamide A inhibits MMP12 by a non-zinc binding mechanism.
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影响因子：
7.4
作者：
Fujii, K;Ikai, Y;Harada, K
通讯作者：
Harada, K
DOI：
10.1073/pnas.0407106102
发表时间：
2005-04-12
影响因子：
11.1
作者：
Bertini, I;Calderone, V;Turano, P
通讯作者：
Turano, P
DOI：
10.1007/bf02908688
发表时间：
1984-01-01
期刊：
CARLSBERG RESEARCH COMMUNICATIONS
影响因子：
--
作者：
MARFEY, P
通讯作者：
MARFEY, P
影响因子：
2.7
作者：
Dublanchet, AC;Ducrot, P;Tertre, A
通讯作者：
Tertre, A
影响因子：
5.6
作者：
Morales, R;Perrier, S;O'Gara, M
通讯作者：
O'Gara, M