Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity
Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity
复制标题
DOI：
10.3390/12071352
复制
发表时间：
2007-07-01
期刊：
影响因子：
4.6
通讯作者：
Bydlowski, Sergio Paulo
中科院分区：
文献类型：
--
作者：
Pereira, Regina M. S.;Andrades, Norma E. D.;Bydlowski, Sergio Paulo
据信，当类黄酮与过渡金属离子配位时，它们的抗氧化活性增加。然而，关于这个问题的文献是矛盾的，结果似乎在很大程度上取决于实验条件。为了了解金属配位的贡献和类黄酮与金属离子之间的相互作用的类型，在这项研究中，一个新的金属配合物的铜（II）与柚皮苷的合成和表征的FT-IR，UV-VIS，质谱（ESI-MS/MS），元素分析和H-1-NMR。这些分析的结果表明，配合物具有通过类黄酮的位置4和5配位的Cu（II）离子。研究了该复合物的抗氧化、抗炎和抑菌活性，并与游离柚皮苷的活性进行了比较。柚金铜(H)复合物1显示出比游离柚皮苷更高的抗氧化、抗炎和肿瘤细胞毒性活性，而不降低细胞活力。
The antioxidant activity of flavonoids is believed to increase when they are coordinated with transition metal ions. However, the literature on this subject is contradictory and the outcome seems to largely depend on the experimental conditions. In order to understand the contribution of the metal coordination and the type of interaction between a flavonoid and the metal ion, in this study a new metal complex of Cu (II) with naringin was synthesized and characterized by FT-IR, UV-VIS, mass spectrometry (ESI-MS/MS), elemental analysis and H-1-NMR. The results of these analyses indicate that the complex has a Cu (II) ion coordinated via positions 4 and 5 of the flavonoid. The antioxidant, anti-inflammatory and antimicrobial activities of this complex were studied and compared with the activity of free naringin. The Naringin-Cu. (H) complex 1 showed higher antioxidant, anti-inflammatory and tumor cell cytoxicity activities than free naringin without reducing cell viability.