Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI
Adenomyosis has no adverse effects on IVF/ICSI outcomes in women with endometriosis treated with long-term pituitary down-regulation before IVF/ICSI
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DOI：
10.1016/j.ejogrb.2010.02.047
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发表时间：
2010-07-01
影响因子：
2.6
通讯作者：
Hompes, P.
中科院分区：
文献类型：
--
作者：
Mijatovic, V.;Florijn, E.;Hompes, P.
目的：探讨子宫内膜异位症不孕症患者在IVF/ICSI前长期使用促性腺激素释放激素激动剂(GnRH-激动剂)对IVF/ICSI结局的影响。研究设计：对2002年1月至2007年3月间74例经手术证实的子宫内膜异位症不孕症患者进行回顾性研究。子宫腺肌病的诊断是基于经阴道超声检查标准。所有患者在IVF/ICSI前均接受长期的GnRH激动剂治疗。结果：90.4%的患者被诊断为子宫内膜异位症，其中27%的患者表现为子宫腺肌症，主要位于子宫后壁。IVF/ICSI的结果如下：IVF/ICSI前GnRH激动剂的平均使用时间为5.35个月(3~26个月)，FSH的平均用量为208IU(75~450个)，平均获卵数为8.73个(1~30个)，平均获得胚胎数为3.86个(0~16个)：平均移植胚胎1.6个；平均受精率43.6%；平均着床率26.3%；平均流产率24.3%；临床妊娠率(超过12周的超声胎心活动)为31.7%。结论：子宫腺肌病对接受长期促性腺激素释放激素激动剂治疗的子宫内膜异位症不孕患者的IVF/ICSI结局没有不良影响。(C)2010爱思唯尔爱尔兰有限公司。保留所有权利。
Objectives: To establish the effect of adenomyosis on IVF/ICSI outcomes in infertile patients with endometriosis who were pretreated with long-term (>= 3 months) GnRH-agonist prior to IVF/ICSI.Study design: Retrospective study in 74 infertile patients with surgically proven endometriosis who were treated with IVF/ICSI between January 2002 and March 2007. The diagnosis of adenomyosis was based on transvaginal ultrasound criteria. All patients were pretreated with long-term (>= 3 months) GnRH-agonist prior to IVF/ICSI.Results: 90.4% of the patients were diagnosed with endometriosis rASRM stages Adenomyosis was demonstrated in 27% of them and was predominantly located in the posterior wall of the uterus. The following IVF/ICSI outcomes were found: a mean duration of GnRH-agonist use prior to IVF/ICSI of 5.35 months (3-26); a mean dosage of FSH used of 208 IU (75-450); the mean number of oocytes retrieved was 8.73 (1-30); the mean number of embryos obtained was 3.86 (0-16): the mean number of embryos transferred was 1.6; a mean fertilization rate of 43.6%; a mean implantation rate of 26.3%; a mean miscarriage rate of 24.3%; and a clinical pregnancy rate (fetal heart activity on ultrasound beyond 12 weeks of gestation) of 31.7%. No significant differences were found for any of the IVF/ICSI outcomes between women with and without adenomyosis.Conclusions: Adenomyosis had no adverse effects on IVF/ICSI outcomes in infertile women with proven endometriosis who were pretreated with long-term GnRH-agonist. (C) 2010 Elsevier Ireland Ltd. All rights reserved.