Association of variants in BAFF (rs9514828 and rs1041569) and BAFF-R (rs61756766) genes with the risk of chronic lymphocytic leukemia.
Association of variants in BAFF (rs9514828 and rs1041569) and BAFF-R (rs61756766) genes with the risk of chronic lymphocytic leukemia.
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DOI：
10.1007/s13277-016-5182-z
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Kusnierczyk, Piotr
中科院分区：
文献类型：
--
作者：
Jasek, Monika;Bojarska-Junak, Agnieszka;Wagner, Marta;Sobczynski, Maciej;Wolowiec, Dariusz;Rolinski, Jacek;Karabon, Lidia;Kusnierczyk, Piotr
B细胞激活因子（BAFF）/BAFF受体（BAFF-R）轴在慢性淋巴细胞白血病（CLL）的发生、发展中起重要作用。在此，我们调查了439例CLL患者和477例对照组中BAFF（TNFSF 13 B）和BAFF-R（TNFRSF 13 C）基因中的8个单核苷酸多态性（SNP）与散发性CLL风险的相关性。我们还检查了所选SNP与CLL临床参数以及BAFF血浆水平和细胞内BAFF表达之间的相关性。我们的研究结果指出了rs 9514828与（CT与CC + TT; OR = 0.74; CI 95%= 0.57; 0.97; p = 0.022）和rs 1041569（AT对AA + TT; OR = 0.72; CI 95%= 0.54; 0.95; p = 0.021）和BAFF-R基因的rs61756766（CC对CT; OR = 2.03; CI 95%= 1.03; 3.99; p = 0.03）与CLL风险。此外，我们观察到纯合子rs 1041569 AA和TT与AT杂合子相比，需要治疗的风险略高（HR = 1.12）。总之，我们的研究结果表明，BAFF和BAFF-R基因的SNPs可能被认为是潜在的CLL的危险因素。本文的在线版本（doi：10.1007/s13277-016-5182-z）包含补充材料，可供授权用户使用。
The B-cell activator factor (BAFF)/BAFF receptor (BAFF-R) axis seems to play an important role in the development and progression of chronic lymphocytic leukemia (CLL). Here, we investigated the association of eight single nucleotide polymorphisms (SNPs) in the BAFF (TNFSF13B) and BAFF-R (TNFRSF13C) genes with risk of sporadic CLL in a group of 439 CLL patients and 477 controls. We also examined the correlation between selected SNPs and CLL clinical parameters as well as BAFF plasma levels and intracellular BAFF expression. Our results point to a possible association between the rs9514828 (CT vs. CC + TT; OR = 0.74; CI 95 % = 0.57; 0.97; p = 0.022) and rs1041569 (AT vs. AA + TT; OR = 0.72; CI 95 % = 0.54; 0.95; p = 0.021) of BAFF gene and rs61756766 (CC vs. CT; OR = 2.03; CI 95 % = 1.03; 3.99; p = 0.03) of BAFF-R gene and CLL risk. Additionally, we observed that homozygotes rs1041569 AA and TT had a slightly higher risk (HR = 1.12) for the need of treatment in comparison to AT heterozygotes. In conclusion, our results indicate that SNPs in BAFF and BAFF-R genes may be considered as potential CLL risk factors. The online version of this article (doi:10.1007/s13277-016-5182-z) contains supplementary material, which is available to authorized users.
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