Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L
Acquired, but not innate, immune responses to Streptococcus pneumoniae are compromised by neutralization of CD40L
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DOI：
10.1128/iai.68.2.511-517.2000
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发表时间：
2000-02-01
影响因子：
3.1
通讯作者：
Purkerson, JM
中科院分区：
文献类型：
--
作者：
Hwang, YI;Nahm, MH;Purkerson, JM
Streptococcus pneumoniae is a significant pathogen of young children and the elderly. Systemic infection by pneumococci is a complex process involving several bacterial and host factors. We have investigated the role of CD40L in host defense against pneumococcal infection. Treatment of mice with MR-I antibody (anti-CD154/CD40L) markedly reduced antibody responses to the pneumococcal protein PspA, elicited by immunization of purified protein or whole bacteria. In mice immunized with whole bacteria, MR-1 treatment reduced antibody responses to capsular polysaccharides but not cell wall polysaccharides. MR-1 did not suppress antibody responses to isolated capsular polysaccharides but did reduce the production of antibody to a capsular polysaccharide-protein conjugate, indicating that when presented in the context of whole bacteria, the humoral response to capsular polysaccharides is partially T-cell dependent. Despite the reduction of the protective humoral responses to pneumococcal infection, administration of MR-1 had no effect on sepsis, lung infection, or nasal carriage in nonimmune mice inoculated with virulent pneumococci. Thus, short-term neutralization of CD40L does not compromise innate host defenses against pneumococcal invasion.
