Comparison of Staphylococcus aureus and Escherichia coli infusion in conscious rats.
Comparison of Staphylococcus aureus and Escherichia coli infusion in conscious rats.
复制标题
清醒大鼠输注金黄色葡萄球菌和大肠杆菌的比较。
DOI：
10.1006/jsre.1994.1010
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Wilson,MF
中科院分区：
文献类型：
--
作者：
Stewart,KD;Brackett,DJ;Lerner,MR;Archer,LT;Wilson,MF
The purpose of this study was to compare the pathophysiology of bacteremia produced by intravenous infusion of either a Gram-positive (Staphylococcus aureus) or a Gram-negative (Escherichia coli) organism. Conscious, unrestrained, instrumented rats receivedS. aureus, E. colior sterile saline over 120 min, followed by a 240-min monitoring period. The infusates produced 90)% (S. aureus,) 80% (E. coli), and 0% (saline) mortality at 24 hr. Neither bacterial group produced hypotension during the entire 360-min study period.E. coliproduced early tachycardia and increased glucose, followed by decreased stroke volume and increased lacrate andpO2.S. aureuscaused early tachycardia followed by decreased pH, stroke volume, and cardiac output and increased lactate and systemic vascular resistance. Respiration rate and central venous pressure were not affected by either bacterial infusion. Compared toE. coli, S. aureusproduced decreased pH, glucose,pO2, heart rate, and cardiac output and increased lactate, hematocrit,pCO2, and systemic vascular resistance. These data document quantitative differences in the acute response of the conscious rat to bacteremia caused by these isolates ofE. coliandS. aureus.
