Synthesis and biological activity of dysiherbaine model compound
Synthesis and biological activity of dysiherbaine model compound
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DOI：
10.1016/s0040-4039(99)00413-x
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发表时间：
1999-04-16
影响因子：
1.8
通讯作者：
Tachibana, K
中科院分区：
文献类型：
--
作者：
Sasaki, M;Maruyama, T;Tachibana, K
报道了地西赫巴因模型化合物2及其非对映异构体3的合成。结构简化的模型化合物2，在四氢吡喃环上缺乏羟基和N-甲基，在脑内注射时诱导小鼠惊厥行为；(C)1999爱思唯尔科学有限公司。保留所有权利。
Synthesis of dysiherbaine model compound 2 and its diastereomer 3 is described. The structurally simplified model compound 2, lacking the hydroxyl and N-methyl groups on the tetrahydropyran ring, induced convulsive behavior in mice upon intracerebral injections; (C) 1999 Elsevier Science Ltd. All rights reserved.