Adulthood Obesity Is Positively Associated with Adipose Tissue Concentrations of Vitamin K and Inversely Associated with Circulating Indicators of Vitamin K Status in Men and Women
Adulthood Obesity Is Positively Associated with Adipose Tissue Concentrations of Vitamin K and Inversely Associated with Circulating Indicators of Vitamin K Status in Men and Women
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DOI：
10.3945/jn.109.118380
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发表时间：
2010-05-01
影响因子：
4.2
通讯作者：
Saltzman, Edward
中科院分区：
文献类型：
--
作者：
Shea, M. Kyla;Booth, Sarah L.;Saltzman, Edward
肥胖的增加与几种脂溶性营养素的储存增加有关。然而，维生素K储存在脂肪中的程度以及维生素K状态与肥胖之间的关联尚不清楚。本研究的目的是确定维生素K是否储存在人体脂肪组织中，以及老年男性和女性维生素K状况与体脂之间的关系。在研究A中，使用HPLC对取自16名胃旁路术患者（13名女性，3名男性，年龄40 ± 10岁（平均值± SD））的样本中皮下和内脏脂肪组织的维生素K浓度进行定量。在研究B中，在260名女性和183名男性[年龄= 68 +/- 5岁]中检查了体脂百分比（%BF）和维生素K状态循环指标之间的横断面相关性。皮下和内脏脂肪组织中的叶绿醌（K-1）浓度分别为148.2 +/- 71.8和175 +/- 112 nmol/kg，高于已知储存维生素K的其他器官的报告浓度。女性BF %与血浆K-1呈负相关（P趋势< 0.001）。较高的%BF与较高的未羧化凝血酶原循环浓度相关，表明男性（P趋势= 0.02）和女性（P趋势= 0.002）的维生素K肝脏利用率较低，但与低羧化骨钙素的百分比无关。脂肪组织中含有高浓度的维生素K，而肥胖的增加与老年人维生素K状况较差有关。需要进一步的研究来进一步探索体脂、脂肪组织中维生素K的储存以及维生素K状态和功能之间的关系。J.营养140：1029-1034，2010.
Increased adiposity is associated with increased storage of several fat-soluble nutrients. However, the extent to which vitamin K is stored in fat and the association between vitamin K status and adiposity are unknown. Our objectives in this study were to determine whether vitamin K is stored in human adipose tissue and the association between vitamin K status and body fat in older men and women. In study A, the vitamin K concentration of subcutaneous and visceral adipose tissue was quantified in samples taken from 16 gastric bypass patients (13 women, 3 men, age 40 +/- 10 y (mean +/- SD)] using HPLC. In study B, cross-sectional associations between percent body fat (%BF) and circulating measures of vitamin K status were examined in 260 women and 183 men [age = 68 +/- 5 y]. The phylloquinone (K-1) concentrations in subcutaneous and visceral adipose tissue were 148.2 +/- 71.8 and 175 +/- 112 nmol/kg, respectively, which is higher than the reported concentrations of other organs known to store vitamin K. There was an inverse association between %BF and plasma K-1 in women (P-trend < 0.001). Higher %BF was associated with greater circulating concentrations of uncarboxylated prothrombin, indicative of lower hepatic utilization of vitamin K in both men (P-trend = 0.02) and women (P-trend = 0.002) but not with the percentage of undercarboxylated osteocalcin. Adipose tissue contained high concentrations of vitamin K, and increased adiposity was associated with poorer vitamin K status in older adults. Additional studies are needed to further explore the relationships among body fat, storage of vitamin K in adipose tissue, and implications for vitamin K status and function. J. Nutr. 140: 1029-1034, 2010.