The three-dimensional cancer genome.
The three-dimensional cancer genome.
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DOI：
10.1016/j.gde.2016.01.002
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发表时间：
2016-02
影响因子：
4
通讯作者：
Corces VG
中科院分区：
文献类型：
--
作者：
Corces MR;Corces VG
过去十年的癌症研究使人们对基因组序列在肿瘤发生过程中的作用有了全面的了解。然而，直到最近才发现表观基因组，特别是染色质的三维拓扑结构与癌症进展有关。在这里，我们回顾了最近的研究结果，癌症基因组是如何调节和失调，以影响3D基因组拓扑结构的变化。我们讨论了基因组的空间组织对致瘤性染色体易位频率的影响，以及负责建立染色质环的蛋白质的破坏的影响。三维癌症基因组的改变是多种癌症亚型的快速出现的标志。
The past decade of cancer research has ushered in a comprehensive understanding of the way that the sequence of the genome can be coopted during the process of tumorigenesis. However, only recently has the epigenome, and in particular the three-dimensional topology of chromatin, been implicated in cancer progression. Here we review recent findings of how the cancer genome is regulated and dysregulated to effect changes in 3D genome topology. We discuss the impact of the spatial organization of the genome on the frequency of tumorigenic chromosomal translocations and the effects of disruption of the proteins responsible for the establishment of chromatin loops. Alteration of the three-dimensional cancer genome is a rapidly emerging hallmark of multiple cancer subtypes.