The C-elegans cell death. specification gene ces-1 encodes a snail family zinc finger protein
The C-elegans cell death. specification gene ces-1 encodes a snail family zinc finger protein
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DOI：
10.1016/s1097-2765(00)80333-0
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发表时间：
1999-09-01
期刊：
影响因子：
16
通讯作者：
Horvitz, HR
中科院分区：
文献类型：
--
作者：
Metzstein, MM;Horvitz, HR
ces-1和ces-2基因在C.线虫控制特定神经元的程序性死亡。遗传证据表明ces-2通过负调节ces-1的保护活性来杀死这些神经元。ces-2编码一种与脊椎动物PAR家族bZIP转录因子密切相关的蛋白质，ces-2/ces-1样途径可能在调节哺乳动物淋巴细胞的程序性细胞死亡中起作用。在这里，我们表明，ces-1编码蜗牛家族锌指蛋白，最相似的序列果蝇神经元分化蛋白划痕。我们定义了一个重要的元素，为CES-1的调节，并提供证据表明，CES-2可以结合到该元素内的一个网站，从而可能直接抑制CES-1转录。我们的研究结果表明，转录级联控制特定细胞的死亡，在C。优雅的。
The ces-1 and ces-2 genes of C. elegans control the programmed deaths of specific neurons. Genetic evidence suggests that ces-2 functions to kill these neurons by negatively regulating the protective activity of ces-l. ces-2 encodes a protein closely related to the vertebrate PAR family of bZIP transcription factors, and a ces-2/ces-1-like pathway may play a role in regulating programmed cell death in mammalian lymphocytes. Here we show that ces-1 encodes a Snail family zinc finger protein, most similar in sequence to the Drosophila neuronal differentiation protein Scratch. We define an element important for ces-1 regulation and provide evidence that CES-2 can bind to a site within this element and thus may directly repress ces-1 transcription. Our results suggest that a transcriptional cascade controls the deaths of specific cells in C. elegans.