Molecular epidemiology of dengue virus serotypes 2 and 3 in Paraguay during 2001-2006: The association of viral clade introductions with shifting serotype dominance
Molecular epidemiology of dengue virus serotypes 2 and 3 in Paraguay during 2001-2006: The association of viral clade introductions with shifting serotype dominance
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DOI：
10.1016/j.virusres.2008.07.011
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发表时间：
2008-11-01
期刊：
影响因子：
5
通讯作者：
Makino, Yoshihiro
中科院分区：
文献类型：
--
作者：
Aquino, Jose D. J. Diaz;Tang, Wei-Feng;Makino, Yoshihiro
为了确定巴拉圭登革病毒（DENV）的遗传变异性，对2001年至2006年分离的4株DENV-2和22株DENV-3毒株的完整包膜基因进行了测序。将序列数据用于贝叶斯系统发育分析，其显示，印度尼西亚DENV-2毒株在美洲/亚洲基因型内分为两个不同的进化枝，从而表明新的DENV-2进化枝的引入可能与2005年DENV-3向DENV-2的优势血清型转变有关，并可能导致DENV-2的爆发。本研究还表明，DENV-3株属于基因型III，其中，几个2006年分离株在其所在的树位置与其余分离株不同。这一新分支的引入可能与2006年DENV-2向DENV-3的优势血清型转变有关，并可能导致DENV-3的流行。需要更多的数据来验证这一假设。(c)2008 Elsevier B. V.保留所有权利。
To determine the genetic variability of dengue viruses (DENVs) in Paraguay, the complete envelope gene was sequenced for 4 DENV-2 and 22 DENV-3 strains isolated from 2001 to 2006. The sequence data were used in Bayesian phylogenetic analyses, which revealed that Paraguayan DENV-2 strains fell into two distinct clades within the American/Asian genotype, thus suggesting that the introduction of a new DENV-2 clade was likely associated with the shift of dominant serotype from DENV-3 to DENV-2 in 2005 and might have caused an outbreak of DENV-2. This study also indicated that DENV-3 strains fell into genotype III, of which, several 2006 isolates varied from the remaining isolates in their tree locations. The introduction of this new clade was likely associated with the shift of dominant serotype from DENV-2 to DENV-3 in 2006 and might have caused an epidemic of DENV-3. More data are needed to test this hypothesis. (c) 2008 Elsevier B.V. All rights reserved.