Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differentiation
Teratoid carcinosarcoma of the ovary with prominent neuroectodermal differentiation
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DOI：
10.1046/j.1440-1827.2001.01275.x
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发表时间：
2001-01-01
影响因子：
2.2
通讯作者：
Sasaguri, Y
中科院分区：
文献类型：
--
作者：
Tanimoto, A;Arima, N;Sasaguri, Y
我们认为这是第二例卵巢畸胎样癌肉瘤。患者为一名59岁女性，因盆腔肿块和腹胀而入院。晚期卵巢癌被诊断出来，并做了肿瘤切除术。肿瘤位于盆腔，肝、脾有转移。实体瘤由软骨肉瘤、鳞癌、腺癌和恶性神经外胚层成分组成，包括神经节神经母细胞瘤样和髓上皮瘤样区。免疫组织化学显示神经外胚层细胞的神经和上皮标记均为阳性。卵巢肿瘤由明显的恶性成分组成，突出的神经外胚层成分与上皮性和间叶性成分以器质性方式混合；相当罕见的肿瘤。
We present what we believe to be only the second report of ovarian teratoid carcinosarcoma. The patient, a 59-year-old woman, was admitted to hospital complaining of a pelvic mass and of abdominal fullness. Advanced ovarian cancer was diagnosed, and a tumorectomy was done. The tumor occupied the pelvis, and metastasis was found in the liver and spleen. The solid tumor was composed of chondrosarcoma, squamous cell carcinoma, adenocarcinoma and malignant neuroectodermal components, which contained ganglioneuroblastoma-like and medulloepithelioma-like areas. Immunohistochemically, the neuroectodermal cells were positive for both neural and epithelial markers. This ovarian tumor consisted of frankly malignant components, with prominent neuroectodermal elements mixed with epithelial and mesenchymal elements in an organoid fashion; a quite rare tumor.