Autoantibodies in postinfectious acute cerebellar ataxia
Autoantibodies in postinfectious acute cerebellar ataxia
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DOI：
10.1212/01.wnl.0000178802.38268.1e
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发表时间：
2005-10-11
期刊：
影响因子：
9.9
通讯作者：
Chiba, A
中科院分区：
文献类型：
--
作者：
Uchibori, A;Sakuta, M;Chiba, A
作者在1例典型的急性小脑性共济失调（ACA）患者血清中发现免疫球蛋白M（IgM）自身抗体，并鉴定其抗原分子为磷酸丙糖异构酶（TPI）。小脑组织中TPI对患者抗体的抗原性最高。与健康对照组相比，23例ACA患者中有8例IgM抗TPI抗体滴度升高。在所有8例患者中，血清学证实了先前的EB病毒感染。抗TPI抗体随临床改善而降低。
The authors found serum immunoglobulin M (IgM) autoantibody in a patient with typical acute cerebellar ataxia (ACA) and identified the antigen molecule as triosephosphate isomerase (TPI). TPI antigenicity to the patient's antibody was the highest in the cerebellar tissue. Eight of 23 patients with ACA had increased IgM anti-TPI antibody titers vs those of healthy controls. Preceding Epstein-Barr virus infection was confirmed serologically in all 8 patients. Anti-TPI antibody decreased with clinical improvement.