Spinal cord ischemia/injury.
Spinal cord ischemia/injury.
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DOI：
10.2174/1381612820666140204113252
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发表时间：
2014-10
影响因子：
3.1
通讯作者：
T. Ishikawa;H. Suzuki;K. Ishikawa;S. Yasuda;T. Matsui;M. Yamamoto;T. Kakeda;S. Yamamoto;Y. Owada;T. Yaksh
中科院分区：
文献类型：
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作者：
T. Ishikawa;H. Suzuki;K. Ishikawa;S. Yasuda;T. Matsui;M. Yamamoto;T. Kakeda;S. Yamamoto;Y. Owada;T. Yaksh
由于白色物质和有髓纤维束的损伤，脊髓损伤导致感觉和运动信号的紊乱。此外，对灰质的损伤导致背角和运动神经元的中间神经元节段性丢失，并限制了治疗选择。神经保护策略有可能改善患者的神经功能结局。为了实现这一目标，麻醉剂或镇痛剂作为神经保护干预措施的关注已经积累，以探索围手术期的神经保护。本文综述了脊髓损伤后病理生理机制的基本概念和具有神经保护作用的麻醉剂和镇痛剂。特别是，我们回顾了异氟烷作为吸入性神经保护剂的应用，并讨论了巴比妥类药物提供的神经保护的证据。此外，3）干细胞生物学、神经损伤和修复的最新进展，以及神经保护和再生干预措施的发展是增加乐观情绪的基础。
A spinal cord injury leads to disturbances of sensory and motor signals due to the damage to white matter and myelinated fiber tracts. Moreover, the damage to gray matter causes segmental loss of interneurons of dorsal horn and motoneurons and restricts the therapeutic options. Neuroprotective strategies have the potential to improve the neurological outcome of patients. To achieve this, concerns to anesthetics or analgesics as neuroprotective interventions have been accumulating to explore neuroprotection during perioperative period. This review includes consideration of: 1) basic concepts of the pathophysiological mechanisms following spinal cord injury and 2) anesthetics and analgesics displaying neuroprotective potential. In particular, we review the application of isoflurane as an inhalational neuroprotectant and discuss evidence for the neuroprotection provided by barbiturates. In addition, 3) recent advances in stem cell biology, neural injury and repair, and progress toward the development of neuroprotective and regenerative interventions are the basis for increased optimism.