The P300 as a possible endophenotype for schizophrenia and bipolar disorder: Evidence from twin and patient studies
The P300 as a possible endophenotype for schizophrenia and bipolar disorder: Evidence from twin and patient studies
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DOI：
10.1016/j.psychres.2008.06.035
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发表时间：
2009-10-30
影响因子：
11.3
通讯作者：
St Clair, David
中科院分区：
文献类型：
--
作者：
Bestelmeyer, Patricia E. G.;Phillips, Louise H.;St Clair, David
有人提出，精神分裂症的心理生理异常，例如诱发电位成分 P300 幅度降低，可能受到遗传影响。 P300 遗传性研究使用了与精神分裂症临床研究不同且通常更复杂的任务。在这里，我们提供了双胞胎样本以及精神分裂症或双相情感障碍患者的同一组听觉和视觉任务上的 P300 参数数据，以检查 P300 作为可能的内表型。来自双胞胎研究的证据表明听觉。但视觉方面则不然，P300 振幅在顶叶中央位点受到遗传影响。同样，精神分裂症和躁郁症患者的听觉 P300 振幅降低，视觉 P300 振幅也有较小程度的降低。结果表明听觉 P300 可能作为精神分裂症的内表型。然而。鉴于精神分裂症和双相情感障碍患者无法通过中线部位的这些测量来区分，看来 P300 可能是一般功能性精神病的标志，而不是精神分裂症特有的标志。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
It has been proposed that psychophysiological abnormalities in schizophrenia, such as decreased amplitude of the evoked potential component P300, may be genetically influenced. Studies of heritability of the P300 have used different and typically more complex tasks than those used in clinical studies of schizophrenia. Here we present data on P300 parameters on the same set of auditory and visual tasks in samples of twins, and patients with schizophrenia or bipolar disorder to examine the P300 as a possible endophenotype. Evidence from the twin study indicated that the auditory. but not visual, P300 amplitude is genetically influenced at centro-parietal sites. Similarly, auditory and to a lesser extent visual P300 amplitude were decreased in schizophrenia and bipolar disorder. Results indicate that the auditory P300 may serve as an endophenotype for schizophrenia. However. given that schizophrenia and bipolar disorder patients could not be distinguished on these measures at midline sites, it appears that the P300 may be a marker for functional psychosis in general rather than being specific to schizophrenia. (C) 2008 Elsevier Ireland Ltd. All rights reserved.