Effects of hypoproteinemia on blood volume and arterial pressure of volume-loaded dogs.
Effects of hypoproteinemia on blood volume and arterial pressure of volume-loaded dogs.
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低蛋白血症对容量负荷犬的血容量和动脉压的影响。
DOI：
10.1152/ajpheart.1990.259.5.h1317
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
ManningJr,RD
中科院分区：
文献类型：
--
作者：
ManningJr,RD
在14只清醒的无肾犬中进行了研究，以阐明血容量在高血压发生中的作用。对犬进行脾切除术，并通过每日血浆置换术将血浆蛋白浓度（PPC）降低至2.7 g/dl，持续9天。这种低蛋白血症导致血容量和平均动脉压下降20%。在第10天，将狗肾切除。在血浆置换3小时对照期后的第11天，静脉输注相当于体重10%或20%的乳酸林格氏液。到输注后25小时，血容量没有增加，犬仍然肿胀。在25 h时，通过静脉输注自体血浆使血浆蛋白质量恢复正常，三个低PPC组的平均血容量增加约50%，动脉压增加大于60%。PPC的降低使钠空间上的血容量回归沿血容量轴向下移动。总之，PPC降低后血容量和动脉压均降低，林格氏输注期间血容量和压力保持不变，血浆输注后血容量和压力均升高，证明了动脉压对血容量的依赖性。
Studies were performed in 14 conscious, anephric dogs to clarify the role of blood volume in the genesis of hypertension. The dogs were splenectomized and had plasma protein concentration (PPC) reduced to 2.7 g/dl by daily plasmapheresis for 9 days. This hypoproteinemia resulted in a 20% decrease in both blood volume and mean arterial pressure. On the 10th day the dogs were nephrectomized. On the 11th day after a 3-h control period with plasmapheresis, lactated Ringer equivalent to 10 or 20% of body weight was intravenously infused. By 25 h postinfusion blood volume had not increased, and the dogs were still hypotensive. At 25 h plasma protein mass was returned to normal by intravenous infusion of autologous plasma, the average blood volume of the three low PPC groups increased approximately 50%, and the arterial pressure increased greater than 60%. The decrease in PPC shifted the regression of blood volume on sodium space down the blood volume axis. In conclusion, the dependence of arterial pressure on blood volume was demonstrated by the decrease in both blood volume and arterial pressure after PPC reduction, the constancy of blood volume and pressure during Ringer infusion, and the increase in both volume and pressure after plasma infusion.