Accumulation of advanced glycation endproducts in patients with systemic lupus erythematosus
Accumulation of advanced glycation endproducts in patients with systemic lupus erythematosus
复制标题
DOI：
10.1093/rheumatology/kem215
复制
发表时间：
2007-10-01
期刊：
影响因子：
5.5
通讯作者：
Bijl, M.
中科院分区：
文献类型：
--
作者：
de Leeuw, K.;Graaff, R.;Bijl, M.
目标。探讨晚期糖基化终产物（age）在系统性红斑狼疮（SLE）患者中是否升高，并与SLE中加速的动脉粥样硬化及其传统和非传统疾病相关危险因素有关。纳入55例SLE非活动性患者和55例年龄和性别匹配的对照组。通过测量UV-A光激发-发射矩阵（AF- eems）来评估皮肤自身荧光（AF）的量，作为AGEs积累的衡量指标。记录传统危险因素和疾病相关因素。评估作为全身性炎症标志物的血浆c反应蛋白（CRP）水平。超声检测颈总动脉内膜-中膜厚度（IMT）。与对照组相比，SLE患者皮肤AF-EEMS增加（1.50 +/- 0.5 a.u vs 1.28 +/- 0.4a.u）。, P = 0.006)。在所有纳入的危险因素中，患者的单因素分析显示AF-EEMS与年龄（r= 0.48， P< 0.001）、IMT （r=0.35， P= 0.01）、肌酐（r= 0.29， P= 0.03）、SLICC损伤指数（r= 0.29， P= 0.03）和病程（r= 0.32， P= 0.02）相关。在多因素分析中，年龄和病程是SLE患者AGEs积累的独立预测因素（P < 0.001， P= 0.03）。与对照组相比，SLE患者的AGES升高。我们的研究结果表明，AGE的积累与疾病持续时间有关，并可能促进SLE患者动脉粥样硬化的加速发展，因此可用于评估长期血管并发症的风险。
Objective. To investigate whether advanced glycation endproducts (AGEs) are increased in patients with systemic lupus erythematosus (SLE), and are related to atherosclerosis, which is accelerated in SLE, and its traditional and non-traditional disease-related risk factors.Methods. Fifty-five SLE patients with inactive disease and 55 age- and sex-matched controls were included. The amount of skin autofluorescence (AF), as a measure for the accumulation of AGEs, was assessed by measuring UV-A light excitation-emission matrices (AF-EEMS). Traditional risk factors and disease-related factors were recorded. Plasma levels of C-reactive protein (CRP), as a marker for systemic inflammation, were assessed. Intima-media thickness (IMT) of the common carotid artery was determined by ultrasound.Results. Skin AF-EEMS was increased in SLE patients as compared with controls (1.50 +/- 0.5 a.u. vs 1.28 +/- 0.4a.u., P=0.006). Regarding all included risk factors, univariate analyses in patients revealed that AF-EEMS was associated with age (r= 0.48, P< 0.001), IMT (r=0.35, P= 0.01), creatinine (r= 0.29, P= 0.03), SLICC damage index (r= 0.29, P= 0.03) and disease duration (r= 0.32, P= 0.02). In multivariate analysis, age and disease duration were independent predictors of accumulation of AGEs in SLE (P < 0.001, P= 0.03, respectively).Conclusion. AGES are increased in SLE compared with controls. Our findings indicate that AGE accumulation is associated with disease duration and might contribute to the development of accelerated atherosclerosis in SLE and, therefore, could be used for assessment of risk for long-term vascular complications.