Biomarkers of oxidative stress are significantly elevated in Down syndrome
Biomarkers of oxidative stress are significantly elevated in Down syndrome
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DOI：
10.1016/s0891-5849(98)00137-3
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发表时间：
1998-12-01
影响因子：
7.4
通讯作者：
MacLeod, K
中科院分区：
文献类型：
--
作者：
Jovanovic, SV;Clements, D;MacLeod, K
有令人信服的流行病学和体外证据表明，慢性氧化应激的个体唐氏综合征（DS）。这些人在30多岁和40多岁时大脑发生类似阿尔茨海默氏症的变化。自身免疫性疾病和白内障的发病率显著增加，整个衰老过程加速。体外研究表明，DS神经元的活力受损，可以通过简单的化学抗氧化剂，如维生素E，BHT和没食子酸丙酯，清楚地表明氧自由基的参与。然而，由于缺乏体内实验，氧化应激在DS中的作用仍然存在争议。我们在这里报告的166个人的尿液样本的化学分析结果，其中DS受试者与他们的兄弟姐妹相匹配。8-羟基-2 '-脱氧鸟苷（DS组2.35 +/- 1.69 vs.对照组1.35 +/- 1.04，P = 0.00011），DNA氧化损伤的生物标志物，和丙二醛（DS组为0.255 +/- 0.158，对照组为0.204 +/- 0.128，P = 0.033），这是一种脂质过氧化的生物标志物，在DS患者中显著升高。饮食影响未能显示出与氧化应激生物标志物的任何显着相关性。这些结果提供了直接的证据，增加氧化应激与DS的个人。
There is convincing epidemiological and in vitro evidence of chronic oxidative stress in individuals with Down syndrome (DS). These individuals develop Alzheimer like changes in the brain in their 30s and 40s. The incidence of autoimmune diseases and cataracts is significantly increased, and the overall ageing process is accelerated. In vitro studies show that impaired viability of DS neurons may be amended by simple chemical antioxidants, such as vitamin E, BHT and propyl gallate, clearly indicative of oxyl radical involvement. However, because of the lack of in vivo experiments, the role of oxidative stress in DS remains controversial. We report here on the results of the chemical analyses of urine samples of 166 individuals, where DS subjects were matched by their siblings. The levels of 8-hydroxy-2'-deoxyguanosine (2.35 +/- 1.69 in DS vs. 1.35 +/- 1.04 in controls, P = 0.00011), a biomarker of oxidative damage to DNA, and malondialdehyde (0.255 +/- 0.158 in DS vs. 0.204 +/- 0.128 in controls, P = 0.033), a biomarker of lipid peroxidation, are significantly elevated in individuals with DS. Dietary influences failed to show any significant correlation with the oxidative stress biomarkers. These results provide direct evidence for increased oxidative stress in individuals with DS.