Metabolism and deposition of propanol and acetone vapors in the upper respiratory tract of the hamster.
Metabolism and deposition of propanol and acetone vapors in the upper respiratory tract of the hamster.
复制标题
丙醇和丙酮蒸气在仓鼠上呼吸道的代谢和沉积。
DOI：
10.1016/0272-0590(87)90151-5
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Cavanagh,DG
中科院分区：
文献类型：
--
作者：
Morris,JB;Cavanagh,DG
丙醇和丙酮蒸气在绵羊上呼吸道的代谢和沉积。莫里斯，J. B.，和卡瓦纳，D。G.（1987）. Fundamental.应用毒理学9，34-40。虽然认为局部代谢可能会增强吸入蒸汽的鼻沉积，但尚未设计研究来定量这种作用。在当前研究中，研究了1-丙醇（代谢蒸汽）和丙酮（非代谢蒸汽）在麻醉叙利亚仓鼠手术分离的上呼吸道（URT）中的沉积。呼吸流速对URT丙酮沉积的影响可以通过通气-灌注（V-P）模型来描述，鼻灌注速率为0.046 ml/min。理论考虑预测，在酶饱和时，沉积效率将取决于吸入浓度，URT代谢率可以从浓度依赖性数据中估计。在200 ml/min的流速下，观察到丙醇沉积效率的浓度依赖性，但在38或71 ml/min时没有。在200 ml/min的流速下，表观URT代谢速率为3.8 Mg/min（95%置信限0.5-7.1 μg/min），鼻组织匀浆的体外研究提供的代谢率约为2 μg/ min，这些数值与沉积研究的估计值没有显著差异，因此与沉积研究的估计值合理一致。校正代谢效应后，URT丙醇沉积可用V-P模型描述，鼻灌注速率为0.050 ml/min。该值与丙酮研究中观察到的值无显著差异。因此，可以用V-P模型描述丙醇和丙酮在叙利亚仓鼠URT中的沉积。代谢似乎增强了丙醇的沉积，但仅在最高吸气流速下观察到该效应，表明鼻通气速率可能影响该蒸汽的总体代谢结局。
Metabolism and Deposition of Propanol and Acetone Vapors in the Upper Respiratory Tract of the Hamster. MORRIS, J. B., AND CAVANAGH, D. G. (1987).Fundam. Appl Toxicol.9, 34–40. While it is thought that local metabolism may enhance nasal deposition of inspired vapors, there have been no studies designed to quantitate this effect. In the current study, deposition of 1-propanol (a metabolized vapor) and acetone (a nonmetabolized vapor) was studied in the surgically isolated upper respiratory tract (URT) of the anesthetized Syrian hamster. The effect of inspiratory flow rate on URT deposition of acetone could be described by a ventilation-perfusion (V-P) model with a nasal perfusion rate of 0.046 ml/min. Theoretical considerations predict that at enzyme saturation, deposition efficiency will be dependent upon the inspired concentration and that URT metabolism rates can be estimated from the concentration-dependence data. A concentration dependence on propanol deposition efficiency was observed at a flow rate of 200 ml/min, but not at 38 or 71 ml/min. At a flow rate of 200 ml/min, an apparent URT metabolism rate of 3.8 Mg/min (95% confidence limits 0.5–7.1 μg/min) was estimated.In vitrostudies on nasal tissue homogenates provided metabolism rates of approximately 2 μg/ min, values which did not differ significantly from, and therefore, were in reasonable agreement with, the estimates from the deposition studies. After correction for the effect of metabolism, URT propanol deposition could be described by the V-P model with a nasal perfusion rate of 0.050 ml/min. This value did not differ significantly from that observed in the acetone studies. Thus, deposition of both propanol and acetone in the URT of the Syrian hamster could be described by the V-P model. Metabolism appeared to enhance deposition of propanol, but the effect was only observed at the highest inspiratory flow rate, suggesting that nasal ventilation rates may influence the overall metabolic fate of this vapor.