Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats
Feeding-entrained circadian rhythms are attenuated by lesions of the parabrachial region in rats
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DOI：
10.1152/ajpregu.2000.278.5.r1296
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发表时间：
2000-05-01
影响因子：
2.8
通讯作者：
Stephan, FK
中科院分区：
文献类型：
--
作者：
Davidson, AJ;Cappendijk, SLT;Stephan, FK
随着接近喂食器的途径增加，核心体温上升，大鼠预计每天都会有限制进餐。食物预期活动(FAA)被认为是由摄食携带的昼夜节律振荡器控制的。虽然许多前脑病变都未能永久消除FAA，但后脑还没有被研究。臂旁核(PBN)整合内脏和味觉传入信息。这一区域也由最后区的神经元支配，这些神经元可以接触到外周循环。因此，该区域可能起到了触发FAA的作用。在两个实验中，总共19只大鼠被给予针对PBN的鹅掌酸或电解性损毁。与假操作的对照组相比，PBN损伤的动物在预期接近食品箱的方式上表现出明显的减弱。一些动物完全没有预料到这顿饭。此外，与对照组相比，PBN组动物的核心体温预期上升幅度严重减弱。对这些数据最有可能的解释是，PBN作为关于Zeitgeber(肠道中的食物)的信息的中继器或作为时钟输出途径，但不作为摄食携带的昼夜节律振荡器的位置。
Rats anticipate daily restricted meals with increased approaches to a feeder and an increase in core body temperature. Food anticipatory activity (FAA) is thought to be under the control of a feeding-entrained circadian oscillator. Although numerous forebrain lesions have failed to permanently abolish FAA, the hindbrain has not been investigated. The parabrachial nuclei (PBN) integrate information from visceral and gustatory afferents. This region is also innervated by neurons in the area postrema that have access to the peripheral circulation. Therefore, it is possible that this region plays a role in triggering FAA. In two experiments, a total of 19 rats were given ibotenic acid or electrolytic lesions targeted at the PBN. The PBN-lesioned animals showed a marked attenuation in anticipatory approaches to the food bin relative to sham-operated controls. Some animals did not anticipate the meal at all. In addition, the expected increase in core body temperature was severely attenuated in the PBN-lesioned animals compared with controls. The most likely interpretation of these data is that the PBN serve as a relay for information about the zeitgeber (food in the gut) or as a clock output pathway, but not as the site of the feeding-entrained circadian oscillator.