Molecular calculations of poly(ethylene glycol) transport across a swollen poly(acrylic acid)/mucin interface.
Molecular calculations of poly(ethylene glycol) transport across a swollen poly(acrylic acid)/mucin interface.
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DOI：
10.1163/156856298x00028
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
N. Peppas
中科院分区：
文献类型：
--
作者：
N. Peppas
在轻交联聚丙烯酸和粘蛋白之间的界面上，聚乙二醇链的运输可以作为分子特性的函数来分析，使用稀网络中的链渗透理论。随后粘合键的断裂能与穿过界面的聚合物链数成正比，而聚合物链数又与聚合物体积分数、链扩散系数和聚合程度有关。相关计算进行了一些交联聚（丙烯酸）凝胶和三种不同类型的聚（乙二醇）链。
The transport of poly(ethylene glycol) chains than can promote mucoadhesion across the interface between lightly cross-linked poly(acrylic acid) and mucin may be analyzed as a function of molecular characteristics using theories of chain penetration in a dilute network. The fracture energy for the ensuing adhesive bond is proportional to the number of polymer chains crossing the interface, which, in turn, is related to the polymer volume fraction, the chain diffusion coefficient, and the degree of polymerization. Relevant calculations were performed for a number of cross-linked poly(acrylic acid) gels and three different types of poly(ethylene glycol) chains.