Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients
Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients
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DOI：
10.1007/s00005-009-0031-z
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发表时间：
2009-08-01
影响因子：
3.2
通讯作者：
Zwozdziak, Barbara
中科院分区：
文献类型：
--
作者：
Szkaradkiewicz, Andrzej;Marciniak, Ryszard;Zwozdziak, Barbara
该研究的目的是描述循环单核细胞/巨噬细胞促炎细胞因子的水平本研究对15名健康个体、20名溃疡性结肠炎（UC）患者、20名结肠直肠癌（CRC）患者、20名结肠直肠癌（CRC）患者和20名结肠直肠癌（CRC）患者进行了研究。克罗恩病（CD）12例，结直肠癌（Dukes' stage B）15例。ELISA法检测血清细胞因子水平，UC患者血清促炎细胞因子和循环IL-10水平显著高于健康对照组。CD和CRC患者具有相同的血清细胞因子特异性模式，即促炎细胞因子水平显著升高，因此，我们的研究结果表明，IBD和CRC都与大量单核细胞/巨噬细胞促炎细胞因子的强化产生有关，而这并不伴随着循环IL-10水平的升高，除了它对UC患者的抑制作用不充分。
The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-alpha, IL-1 beta IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls.The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn's disease (CD), and 15 with CRC (Dukes' stage B). Blood serum cytokine levels were measured by ELISA.The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals.Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.