Management of adult acute lymphoblastic leukemia: moving toward a risk-adapted approach.
Management of adult acute lymphoblastic leukemia: moving toward a risk-adapted approach.
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成人急性淋巴细胞白血病的管理：转向风险适应方法。
DOI：
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发表时间：
2001
影响因子：
3.4
通讯作者：
Wendy Stock
中科院分区：
文献类型：
--
作者：
A. Verma;Wendy Stock;Wendy Stock
绝大多数急性淋巴细胞白血病（ALL）成人患者现在通过目前的强化化疗方案获得缓解。然而，大多数成人ALL患者最终会复发并死于疾病。特定的临床和分子细胞遗传学预后因素已被确定，开始为风险适应性管理策略的发展提供见解，这些策略似乎可以提高几个高危患者群体的生存率，包括成熟B细胞ALL和费城染色体的B系ALL患者。我们回顾了成人ALL的标准和一些最近描述的预后因素，描述了基于风险适应方法的当前治疗，并展望未来，简要讨论了可纳入缓解后策略以提高成人ALL生存率的新型靶向治疗。
The vast majority of adults with acute lymphoblastic leukemia (ALL) now achieve remission with current intensive chemotherapy regimens. Nevertheless, most adults with ALL will eventually relapse and die of their disease. Specific clinical and molecular-cytogenetic prognostic factors have been identified that are beginning to provide insights for the development of risk-adapted management strategies that appear to improve survival for several high-risk patient groups, including those with mature B-cell ALL and B-lineage ALL patients with a Philadelphia chromosome. We review standard and some recently described prognostic factors in adult ALL, describe current therapy based on a risk-adapted approach, and look toward the future with a brief discussion of novel, targeted treatments that could be incorporated into postremission strategies to improve survival for adults with ALL.
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影响因子：
20.3
作者：
W. Stock;T. Tsai;C. Golden;C. Rankin;Dorrie Sher;M. Slovak;M. Pallavicini;J. Radich;D. Boldt
通讯作者：
W. Stock;T. Tsai;C. Golden;C. Rankin;Dorrie Sher;M. Slovak;M. Pallavicini;J. Radich;D. Boldt
成人急性淋巴细胞白血病的前瞻性核型分析：癌症和白血病 B 组经验。
影响因子：
20.3
作者：
Wetzler,M;Dodge,RK;Mrózek,K;Carroll,AJ;Tantravahi,R;Block,AW;Pettenati,MJ;LeBeau,MM;Frankel,SR;Stewart,CC;Szatrowski,TP;Schiffer,CA;Larson,RA;Bloomfield,CD
通讯作者：
Bloomfield,CD
影响因子：
20.3
作者：
BENSINGER, WI;WEAVER, CH;BUCKNER, CD
通讯作者：
BUCKNER, CD
影响因子：
20.3
作者：
LARSON, RA;DODGE, RK;SCHIFFER, CA
通讯作者：
SCHIFFER, CA
影响因子：
20.3
作者：
S. Forman;M. O'donnell;A. Nademanee;D. Snyder;P. Bierman;G. M. Schmidt;J. Fahey;A. Stein;P. Parker;K. Blume
通讯作者：
S. Forman;M. O'donnell;A. Nademanee;D. Snyder;P. Bierman;G. M. Schmidt;J. Fahey;A. Stein;P. Parker;K. Blume