Salt, salt sensitivity, and the endothelium: a pathway to discovery of molecular mechanisms.
Salt, salt sensitivity, and the endothelium: a pathway to discovery of molecular mechanisms.
复制标题
盐、盐敏感性和内皮：发现分子机制的途径。
DOI：
10.1161/hypertensionaha.113.02085
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Agarwal,Rajiv
中科院分区：
文献类型：
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作者：
Agarwal,Rajiv
832 Hypertension November 2013 nitric oxide synthase. Elevation in blood pressure would then be a reflection of nitric oxide synthase activity. Thus, L-NMMA response to blood pressure was used as a biomarker of NO activity. In the Dahl salt-resistant rats, baseline levels of mean arterial pressure (MAP) were similar, despite high salt feeding for 2 weeks; an expected response, given that these animals are resistant to salt feeding. A 21% increase in MAP was seen in animals treated with low-Na diet but a 31% increase with high-Na diet. These data suggest that NO production was stimulated with high salt feeding in salt-resistant animals. This fact was uncovered by greater increase in MAP with L-NMMA in high-Na–treated animals. Further experiments revealed that salt-sensitive animals seem to be different from salt-resistant animals in that no NO stimulation occurs with Na feeding. This raises the possibility that these animals have a defect in endothelial function that underlies the salt sensitivity.Awake unrestrained salt-sensitive rats did not develop hypertension when given L-arginine orally, despite consuming a high-salt diet. In contrast, D-arginine–treated animals were significantly hypertensive by day 2. Prevention of hypertension occurred in a dose–response fashion. L-Arginine did not lower blood pressure in the salt-resistant animals. In separate experiments, L-arginine supplementation did not prevent the development of hypertension in the spontaneously hypertensive rats indicating this mechanism to be specific to the Dahl rats. These observations were confirmed further by demonstrating that intraperitoneal injections of L-arginine in high-salt diet–fed salt-sensitive animals did not result in the development of hypertension. In contrast, injections of D-arginine did not protect from increased MAP. In L-arginine–
