FINE-STRUCTURE OF THE CENTRAL MYELIN SHEATH IN THE MYELIN DEFICIENT MUTANT SHIVERER MOUSE, WITH SPECIAL REFERENCE TO THE PATTERN OF MYELIN FORMATION BY OLIGODENDROGLIA
FINE-STRUCTURE OF THE CENTRAL MYELIN SHEATH IN THE MYELIN DEFICIENT MUTANT SHIVERER MOUSE, WITH SPECIAL REFERENCE TO THE PATTERN OF MYELIN FORMATION BY OLIGODENDROGLIA
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DOI：
10.1016/0006-8993(81)90269-9
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发表时间：
1981-01-01
期刊：
影响因子：
2.9
通讯作者：
TSUKADA, Y
中科院分区：
文献类型：
--
作者：
INOUE, Y;NAKAMURA, R;TSUKADA, Y
对隐性常染色体突变小鼠SWITVER的中央髓鞘进行了光镜观察，并结合髓鞘形成模式进行了研究。髓鞘板层的主要致密线一般不能形成，但轴突被apprx的三层板层结构所包裹。14 nm宽，由1片相邻少突胶质细胞胞质片的外叶融合而成的中央膜和2片与相邻胞质片的内叶相同的高电子密度的外膜组成。主要致密线呈零星分布。髓鞘不是由少突胶质细胞的1个胞质突起螺旋形成的，而是通过包围轴突而形成的，其中一些胞质片层是由1个突起的分裂形成的。异常髓鞘形成常发生在少突胶质细胞胞体周围，与轴突无关。
The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by EM with special reference to the pattern of myelin formation. The major dense line of myelin lamellae generally failed to be formed, but the axons were enclosed by tri-lamellar structures of .apprx. 14 nm in width, which were composed of 1 central membrane formed by fusion of outer leaflets of adjacent cytoplasmic sheets of oligodendroglia, corresponding to the intraperiod line, and 2 outer membranes which were identical with inner leaflets of adjacent cytoplasmic sheets and became highly electron-dense. Major dense lines were sporadically observed. The myelin sheath was not generated formed by spiraling of 1 cytoplasmic process of the oligodendroglia, but by enclosing an axon with several stratified layers of cytoplasmic sheets, some of which were certain formed by the splitting of 1 process. Aberrant myelination frequently occurred around the soma of oligodendroglia, not related to any axons.