Imaging human intra-cerebral connectivity by PET during TMS
Imaging human intra-cerebral connectivity by PET during TMS
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DOI：
10.1097/00001756-199708180-00027
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发表时间：
1997-08-18
期刊：
影响因子：
1.7
通讯作者：
Jerabek, P
中科院分区：
文献类型：
--
作者：
Fox, P;Ingham, R;Jerabek, P
在经颅磁刺激（TMS）期间，通过正电子发射断层扫描（PET）对人类区域间神经连接进行无创成像。用TMS刺激左侧大脑半球初级运动皮层（M1）的手区，同时用PET记录局部和远程效应。在刺激部位，TMS以高度集中的方式增加血流量（12-20%），而没有抑制性环绕。远程协方差，与M1的连接性指数，也是焦点。在非人类物种中建立的连接模式得到了普遍确认。在同侧初级和次级躯体感觉区（S1和S2）、同侧腹侧、外侧运动前区（M2）和对侧补充运动区（SMA）观察到兴奋性连接（正协方差）。在对侧M1中观察到抑制性连接（负协方差）。
NON-INVASIVE imaging of human inter-regional neural connectivity by positron emission tomography (PET) during transcranial magnetic stimulation (TMS) was performed. The hand area of primary motor cortex (M1) in the left cerebral hemisphere was stimulated with TMS while local and remote effects were recorded with PET. At the stimulated site, TMS increased blood flow (12-20%) in a highly focal manner, without an inhibitory surround. Remote covariances, an index of connectivity with M1, were also focal. Connectivity patterns established in non-human species were generally confirmed. Excitatory connectivity (positive covariance) was observed in ipsilateral primary and secondary somatosensory areas (S1 and S2), in ipsilateral ventral, lateral premotor cortex (M2) and in contralateral supplementary motor area (SMA). Inhibitory connectivity (negative covariance) was observed in contralateral M1.