Association of Urinary Sodium and Potassium Excretion with Blood Pressure
Association of Urinary Sodium and Potassium Excretion with Blood Pressure
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DOI：
10.1056/nejmoa1311989
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发表时间：
2014-08-14
影响因子：
158.5
通讯作者：
Yusuf, Salim
中科院分区：
文献类型：
--
作者：
Mente, Andrew;O'Donnell, Martin J.;Yusuf, Salim
背景高水平的钠摄入量与高血压有关。这种关系是否会因钠或钾的摄入水平以及不同人群而异尚不清楚。24小时钠和钾排泄量的估计值由单个空腹晨尿标本得出，并用作摄入量的替代品。我们评估了电解质排泄和血压之间的关系，与一个自动化的device.ResultsRegression分析显示，在收缩压和舒张压为每1克的增量估计钠排泄量为2.11毫米汞柱和0.78毫米汞柱的增量。随着钠摄入量的增加，这种关联的斜率越陡（钠排泄量>5 g/天，收缩压每克增加2.58 mm Hg，每天排泄3至5 g，收缩压每克增加1.74 mm Hg，每天排泄3至5 g，收缩压每克增加0.74 mm Hg）。
BackgroundHigher levels of sodium intake are reported to be associated with higher blood pressure. Whether this relationship varies according to levels of sodium or potassium intake and in different populations is unknown.MethodsWe studied 102,216 adults from 18 countries. Estimates of 24-hour sodium and potassium excretion were made from a single fasting morning urine specimen and were used as surrogates for intake. We assessed the relationship between electrolyte excretion and blood pressure, as measured with an automated device.ResultsRegression analyses showed increments of 2.11 mm Hg in systolic blood pressure and 0.78 mm Hg in diastolic blood pressure for each 1-g increment in estimated sodium excretion. The slope of this association was steeper with higher sodium intake (an increment of 2.58 mm Hg in systolic blood pressure per gram for sodium excretion >5 g per day, 1.74 mm Hg per gram for 3 to 5 g per day, and 0.74 mm Hg per gram for