Mixed Metal-Organic Framework Mixed-Matrix Membranes: Insights into Simultaneous Moisture-Triggered and Catalytic Delivery of Nitric Oxide using Cryo-scanning Electron Microscopy.
Mixed Metal-Organic Framework Mixed-Matrix Membranes: Insights into Simultaneous Moisture-Triggered and Catalytic Delivery of Nitric Oxide using Cryo-scanning Electron Microscopy.
复制标题
DOI：
10.1021/acsami.3c11283
复制
发表时间：
2023-10-25
影响因子：
9.5
通讯作者：
Morris, Russell E.
中科院分区：
文献类型：
--
作者：
Ettlinger, Romy;Vornholt, Simon M.;Roach, Madeline C.;Tuttle, Robert R.;Thai, Jonathan;Kothari, Maadhav;Boese, Markus;Holwell, Andy;Duncan, Morven J.;Reynolds, Melissa;Morris, Russell E.
关键词：
金属有机框架（MOFs）的基本化学和结构多样性是巨大的，但缺乏对这些极其通用的化合物的工业采用。为了弥合基础研究和工业之间的差距，必须将MOF粉末配制成与应用更相关的形状和/或复合材料。在薄的聚合物膜中成功地结合不同比例的两种不同的MOF，CPO-27-Ni和CuBTTri，代表了朝着开发混合的MOF混合基质膜的重要一步。为了深入了解两种不同的MOFs在聚合物中的分布，我们报告了他们的调查冷冻扫描电子显微镜（Cryo-SEM）断层扫描，最大限度地减少表面充电和电子束引起的损伤。由于MOF基于两种不同的金属离子Ni和Cu，因此MOF复合横截面的元素图清楚地识别了重建的3D模型中每个MOF的大小和位置。断层扫描的运行速度比传统的聚焦离子束（FIB）-SEM快六倍，并且可以实现与机器学习相结合的图像分割的第一个见解。为了验证MOF复合材料结合了从CPO-27-Ni快速湿气触发释放一氧化氮（NO）与从CuBTTri连续催化生成NO的益处，我们表征了它们单独和同时递送NO的能力。这些MOF复合材料显示出在现实世界的医疗应用中实现最佳双NO递送的巨大前景。
The fundamental chemical and structural diversity of metal–organic frameworks (MOFs) is vast, but there is a lack of industrial adoption of these extremely versatile compounds. To bridge the gap between basic research and industry, MOF powders must be formulated into more application-relevant shapes and/or composites. Successful incorporation of varying ratios of two different MOFs, CPO-27-Ni and CuBTTri, in a thin polymer film represents an important step toward the development of mixed MOF mixed-matrix membranes. To gain insight into the distribution of the two different MOFs in the polymer, we report their investigation by Cryo-scanning electron microscopy (Cryo-SEM) tomography, which minimizes surface charging and electron beam-induced damage. Because the MOFs are based on two different metal ions, Ni and Cu, the elemental maps of the MOF composite cross sections clearly identify the size and location of each MOF in the reconstructed 3D model. The tomography run was about six times faster than conventional focused ion beam (FIB)-SEM and the first insights to image segmentation combined with machine learning could be achieved. To verify that the MOF composites combined the benefits of rapid moisture-triggered release of nitric oxide (NO) from CPO-27-Ni with the continuous catalytic generation of NO from CuBTTri, we characterized their ability to deliver NO individually and simultaneously. These MOF composites show great promise to achieve optimal dual NO delivery in real-world medical applications.
登录
查看更多内容
影响因子：
5.9
作者：
Main, Russell M.;Vornholt, Simon M.;Rice, Cameron M.;Elliott, Caroline;Russell, Samantha E.;Kerr, Peter J.;Warren, Mark R.;Morris, Russell E.
通讯作者：
Morris, Russell E.
影响因子：
9.5
作者：
Neufeld MJ;Lutzke A;Jones WM;Reynolds MM
通讯作者：
Reynolds MM
影响因子：
9.5
作者：
Carja, Ionela-Daniela;Tavares, Sergio Rodrigues;Maurin, Guillaume
通讯作者：
Maurin, Guillaume
用于双发光比率温度传感的 MOF-纳米复合材料混合基质膜
影响因子：
9
作者：
Ding, Yanyun;Lu, Yantong;Chen, Banglin
通讯作者：
Chen, Banglin
影响因子：
56.7
作者：
Ghalei, Behnam;Sakurai, Kento;Sivaniah, Easan
通讯作者：
Sivaniah, Easan