Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.
Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis.
复制标题
DOI：
10.4049/jimmunol.1300714
复制
发表时间：
2013-08-15
期刊：
影响因子：
--
通讯作者：
Gabrilovich DI
中科院分区：
文献类型：
--
作者：
Liu H;Zhou J;Cheng P;Ramachandran I;Nefedova Y;Gabrilovich DI
虽然树突状细胞（DC）前体的积累发生在骨髓（BM）中，但这些细胞的终末分化发生在BM之外。调节这一过程的信号传导仍然知之甚少。我们证明了这个过程可以通过Notch配体：Jaged-1（Jag 1）和Delta样配体1（Dll 1）进行差异调节。与Dll 1相反，Jag 1在体外和体内诱导骨髓生成期间通过促进其前体的积累来阻止DC分化。虽然这两种配体在造血祖细胞（HPC）中激活Notch，但它们对Wnt信号传导具有相反的作用。Dll 1激活Wnt通路;而Jag 1通过下调Wnt受体Frizzled（Fzd）的表达来抑制Wnt通路。Jag 1通过在fzd启动子上保留与转录因子CSL/CBF-1的复合物中的组蛋白去乙酰化酶1来抑制fzd表达。我们的研究结果表明，DC分化，在诱导骨髓，可以调节的Notch配体表达在相邻的基质细胞的性质。
Although accumulation of dendritic cell (DC) precursors occurs in bone marrow (BM), the terminal differentiation of these cells takes place outside BM. The signaling, regulating this process, remains poorly understood. We demonstrated that this process could be differentially regulated by Notch ligands: Jagged-1 (Jag1) and Delta-like ligand 1 (Dll1). In contrast to Dll1, Jag1, in vitro and during induced myelopoiesis in vivo, prevented DC differentiation by promoting the accumulation of their precursors. Although both ligands activated Notch in hematopoietic progenitor cells (HPC), they had an opposite effect on Wnt signaling. Dll1 activated Wnt pathways; whereas, Jag1 inhibited it via down-regulation of the expression of the Wnt receptors Frizzled (Fzd). Jag1 suppressed fzd expression by retaining histone deacetylase 1 in the complex with the transcription factor CSL/CBF-1 on the fzd promoter. Our results suggest that DC differentiation, during induced myelopoiesis, can be regulated by the nature of the Notch ligand expressed on adjacent stroma cells.
登录
查看更多内容
DOI：
10.1084/jem.20062648
发表时间：
2007-07-09
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Caton ML;Smith-Raska MR;Reizis B
通讯作者：
Reizis B
DOI：
10.1073/pnas.96.1.23
发表时间：
1999-01-05
影响因子：
11.1
作者：
Hsieh, JJD;Zhou, SF;Hayward, SD
通讯作者：
Hayward, SD
影响因子：
5.5
作者：
Hoshino, N;Katayama, N;Shiku, H
通讯作者：
Shiku, H
影响因子：
64.5
作者：
Benedito, Rui;Roca, Cristina;Adams, Ralf H.
通讯作者：
Adams, Ralf H.
影响因子：
20.3
作者：
Li, Haiyan S.;Yang, Cliff Y.;Watowich, Stephanie S.
通讯作者：
Watowich, Stephanie S.