Siderophore piracy enhances Vibrio cholerae environmental survival and pathogenesis.
Siderophore piracy enhances Vibrio cholerae environmental survival and pathogenesis.
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DOI：
10.1099/mic.0.000975
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发表时间：
2020-10
期刊：
影响因子：
1.5
通讯作者：
Hyuntae Byun;I-Ji Jung;Jiandong Chen;Jessie Larios Valencia;Jay Zhu
中科院分区：
文献类型：
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作者：
Hyuntae Byun;I-Ji Jung;Jiandong Chen;Jessie Larios Valencia;Jay Zhu
霍乱弧菌是霍乱的病原体，具有多种铁获取系统，包括运输铁载体的系统。这些系统如何使环境环境中或感染期间的低铁、多微生物群落中的霍乱弧菌受益仍然知之甚少。在这里，我们证明了在铁限制条件下，与一些单独的铁载体生产微生物的共培养的V. cholesterol显着促进V. cholesterol体外生长。我们进一步表明，在低铁的宿主环境中，在产生铁载体的大肠杆菌的存在下，霍乱弧菌在成年小鼠中更好地定殖。综上所述，我们的研究结果表明，在水生水库或感染期间，霍乱弧菌可能通过劫持其他微生物的铁载体来克服环境和宿主的铁限制。
Vibrio cholerae, the aetiological agent of cholera, possesses multiple iron acquisition systems, including those for the transport of siderophores. How these systems benefit V. cholerae in low-iron, polymicrobial communities in environmental settings or during infection remains poorly understood. Here, we demonstrate that in iron-limiting conditions, co-culture of V. cholerae with a number of individual siderophore-producing microbes significantly promoted V. cholerae growth in vitro. We further show that in the host environment with low iron, V. cholerae colonizes better in adult mice in the presence of the siderophore-producing commensal Escherichia coli. Taken together, our results suggest that in aquatic reservoirs or during infection, V. cholerae may overcome environmental and host iron restriction by hijacking siderophores from other microbes.