The Total Synthesis of Hyperforin
The Total Synthesis of Hyperforin
复制标题
金丝桃素的全合成
DOI：
10.1055/s-0035-1561619
复制
发表时间：
2016
期刊：
影响因子：
2
通讯作者：
Maimone, Thomas
中科院分区：
文献类型：
--
作者：
Ting, Chi;Maimone, Thomas
自四十多年前被分离出来以来，金丝桃素一直是一个受欢迎且具有挑战性的合成靶点。因此，人们开发了许多合成策略和成环反应来解决其强大的分子结构。在此，我们描述了我们对该领域的贡献，通过新颖的双烯酮成环反应和氧化环扩展策略实现了十步合成途径。
Hyperforin has remained a popular and challenging synthetic target since its isolation over forty years ago. As a result, numerous synthetic strategies and ring-forming reactions have been developed to address its formidable molecular architecture. Herein we describe our contributions to this area resulting in a ten-step synthetic pathway enabled by a novel diketene annulation reaction and oxidative ring expansion strategy.